Metastases are responsible for the majority of cancer-related deaths. Although genomic
heterogeneity within primary tumors is associated with relapse, heterogeneity among …

The extent of heterogeneity among driver gene mutations present in naturally occurring
metastases—that is, treatment-naive metastatic disease—is largely unknown. To address …

Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal
evolution and impact of treatment are poorly understood. We analyzed whole-exome …

Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication.
Any two randomly selected cells, whether normal or cancerous, are therefore genetically …

When do cancer cells acquire metastatic identity? Recent reports have indicated that the
propensity to metastasize might be hardwired early during tumor development. Now it …

Therapeutic advances in oncology have not fully translated to the treatment of metastatic
disease, which remains largely incurable. Metastatic subclones can emerge both early and …

Metastasis is the principal event leading to death in individuals with cancer, yet its molecular
basis is poorly understood 1. To explore the molecular differences between human primary …

Metastasis remains the leading cause of cancer-associated mortality, and a detailed
understanding of the metastatic process could suggest new therapeutic avenues. However …

Genetic diversity among metastases is poorly understood but contains important information
about disease evolution at secondary sites. Here we investigate inter-and intra-lesion …

Human tumors show a high level of genetic heterogeneity, but the processes that influence
the timing and route of metastatic dissemination of the subclones are unknown. Here we …