OBJECTIVES: Mechanisms of chest pain in gastroesophageal reflux disease (GERD) are
poorly understood. The recent demonstration in healthy subjects that lower esophageal acid …

Functional chest pain is a common, yet poorly understood entity. The focus of this review is
to explore the evolving research and clinical approaches with a particular emphasis on the …

Background Several major schools of thought have emerged in the etiology of noncardiac
chest pain: acid reflux, motor disorder, altered pain threshold/hypersensitivity, and …

Esophageal acid exposure is believed to be a major source of unexplained chest pain; but,
individual episodes of reflux in pH study are not consistently associated with chest pain. Our …

Background: Sensitization of esophageal chemoreceptors, either directly by intermittent acid
exposure or indirectly through esophagitis-associated inflammatory mediators, is likely to be …

Chest pain of esophageal origin or noncardiac chest pain is reported by at least a fifth of the
general population. Recent literature focused on further understanding mechanisms of chest …

Patients with gastroesophageal reflux disease (GERD) experience a wide spectrum of
symptoms, varying both in quality and severity. This review summarizes clinical observations …

Chest pain of esophageal origin is the most common atypical/extraesophageal
manifestation of gastroesophageal reflux disease (GERD). We are increasingly recognizing …

OBJECTIVES As visceral afferents from different regions of the gastrointestinal tract
converge at the level of the spinal cord, we hypothesized that sensitization of one gut organ …

OBJECTIVE: The pathogenesis of noncardiac chest pain is unclear. Increased
gastroesophageal reflux and decreased pain thresholds to intraesophageal balloon …