Biocompatibility and safety of PLA and its copolymers

Y Ramot, M Haim-Zada, AJ Domb, A Nyska - Advanced drug delivery …, 2016 - Elsevier
PLA and its copolymers are commonly used for a wide variety of applications. While they are
considered to be biocompatible, side effects resulting from their implantation have been …

Biopolymers in medical implants: a brief review

R Rebelo, M Fernandes, R Fangueiro - Procedia engineering, 2017 - Elsevier
Biopolymers have been established as a promising class of materials with a wide range of
applications, of which medicine stands out. Characteristics such as biocompatibility …

Technique to control pH in vicinity of biodegrading PLA‐PGA implants

CM Agrawal, KA Athanasiou - Journal of biomedical materials …, 1997 - Wiley Online Library
This in vitro study was performed to examine if the pH decrease in the vicinity of degrading
polylactic acid (PLA) and polyglycolic acid (PGA) polymers can be offset by incorporation of …

Poly lactic acid (PLA) polymers: from properties to biomedical applications

F Ebrahimi, H Ramezani Dana - International Journal of Polymeric …, 2022 - Taylor & Francis
Polylactic acid (PLA), one of the well-known bioabsorbable and compostable polyesters has
rapidly evolved into a competitive commodity material over the last decades. To provide …

PLGA/PVA hydrogel composites for long-term inflammation control following sc implantation

U Bhardwaj, R Sura, F Papadimitrakopoulos… - International journal of …, 2010 - Elsevier
Dexamethasone loaded PLGA microsphere/PVA hydrogel composites were investigated as
an outer drug-eluting coating for implantable devices to provide protection against the …

Biomedical applications of poly (lactic acid)

RP Pawar, SU Tekale, SU Shisodia… - Recent patents on …, 2014 - ingentaconnect.com
Polylactic acid (PLA) is a biodegradable, biocompatible, non-toxic and eco-friendly polymer.
PLA and its composites are currently used in medical implants, tissue engineering …

Polylactic acid (PLA) controlled delivery carriers for biomedical applications

B Tyler, D Gullotti, A Mangraviti, T Utsuki… - Advanced drug delivery …, 2016 - Elsevier
Polylactic acid (PLA) and its copolymers have a long history of safety in humans and an
extensive range of applications. PLA is biocompatible, biodegradable by hydrolysis and …

Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems

D Da Silva, M Kaduri, M Poley, O Adir, N Krinsky… - Chemical Engineering …, 2018 - Elsevier
Polylactic acid (PLA) is the most commonly used biodegradable polymer in clinical
applications today. Examples range from drug delivery systems, tissue engineering …

Differential degradation rates in vivo and in vitro of biocompatible poly (lactic acid) and poly (glycolic acid) homo-and co-polymers for a polymeric drug-delivery …

ACR Grayson, G Voskerician, A Lynn… - Journal of …, 2004 - Taylor & Francis
The biocompatibility and biodegradation rate of component materials are critical when
designing a drug-delivery device. The degradation products and rate of degradation may …

Degradation of poly (D, L) lactide implants with or without addition of calciumphosphates in vivo

W Heidemann, S Jeschkeit, K Ruffieux, JH Fischer… - Biomaterials, 2001 - Elsevier
The study was aimed at examining the in vivo degradation of pure poly (d, l) lactide (PDLLA)
or PDLLA with an admixture of calciumphosphates. One rod (20× 3× 2mm) and one cube …