To complement a project toward label‐free optical biopsy and enhanced resection which the
overall goal is to develop a multimodal nonlinear endomicroscope, this multimodal …

Label-free imaging techniques are gaining acceptance within the medical imaging field,
including brain imaging, because they have the potential to be applied to intraoperative in …

Nonlinear multimodal microscopy offers a series of label‐free techniques with potential for
intraoperative identification of tumor borders in situ using novel endoscopic devices. Here …

Intraoperative imaging in surgical oncology can provide information about the tumor
microenvironment as well as information about the tumor margin. Visualizing microstructural …

The primary therapeutic approach for high-grade brain tumor is surgical resection. However,
identifying tumor margins in vivo remains a major challenge. Biopsy analysis remains the …

This manuscript reports on the first two-photon, label-free, metabolic imaging of biological
tissues in vivo at histological resolution on an extremely compact, fiber-optic …

Significance: Needle biopsy (NB) procedures are important for the initial diagnosis of many
types of cancer. However, the possibility of NB specimens being unable to provide …

Meningioma is the most common primary intracranial extra-axial tumor. Total surgical
removal is the standard therapeutic method to treat this type of brain tumors. However, the …

Accurate intraoperative tumour margin assessment is a major challenge in neurooncology,
where sparse tumours beyond the bulk tumour are left undetected under conventional …

Multiphoton excitation fluorescent microscopy is a laser-based technology that allows
subcellular resolution of native tissues in situ. We have recently applied this technology to …