Data on familial recurrence rates of complex diseases such as multiple sclerosis give
important hints to aetiological factors such as the importance of genes and environment. By …

Multiple sclerosis (MS) is known to accumulate within families. The magnitude of the familial
risk, however, remains uncertain. Using a nationwide MS register and other national …

Familial aggregation is a cardinal epidemiological feature of multiple sclerosis, but few
investigators have systematically examined recurrence risks for relatives of affected …

A genetic contribution to susceptibility is well established in multiple sclerosis (MS) and 57
associated genetic loci have been identified. We have undertaken a meta-analysis of …

In the era of complex disease genetics, the consideration of familial risks is important in the
assessment of the likely success of these studies. In the present article, we study familial …

Objective: Genetic and environmental factors have important roles in multiple sclerosis (MS)
susceptibility. The precise nature of these factors and mode of inheritance remains …

Background: Family structure, such as having siblings, provides proxy measures for a variety
of characteristics relevant to disease risk. The etiology of multiple sclerosis (MS) is not well …

Objective To investigate the parental relationship of patients with multiple sclerosis (MS)
from an extended pedigree with extensive genealogical information up to the middle of the …

Increasingly, MS patients ask neurologists about the risk that their close relatives will also
develop MS. We calculated age-adjusted empiric recurrence risks from data on 815 index …

Epidemiological studies have implicated an interplay between genetic and environmental
factors in the aetiology of multiple sclerosis (MS). There is a familial recurrence rate of …