Adenoviruses contain genes that have evolved to control the host immune and inflammatory
responses; however, it is not clear whether these genes function primarily to facilitate …

This manuscript will contain a brief review of adenovirus (Ad) biology including its structure
and the spectrum of clinical diseases that it causes. Newer findings about the interactions of …

Adenoviruses (Ads) contain more than 20 genes dedicated to control various aspects of the
innate or acquired immune responses of the infected host. Some of these functions are not …

Objectives: Adenoviral vectors are used in transferring exogenous genes to a variety of cells
and tissue types both in vitro and in vivo. Gene expression changes induced by an E1/E3 …

First-generation adenovirus (Ad) gene therapy vectors deleted for the E1A, E1B, and E3
regions and carrying foreign genes under the control of strong foreign promoters induce …

Adenovirus vectors are extensively studied in experimental and clinical models as agents for
gene therapy. Recent generations of helper-dependent adenovirus vectors have the …

Replication-defective human adenovirus (Ad) group C transducing vectors, most of which
have the E1A, E1B, and E3 genes deleted, are highly inflammatory despite the fact that the …

To resist viral infections, leukocytes perform effector functions, such as direct killing of
infected cells (elicited by natural killer cells and T lymphocytes) and production of …

The group C adenoviruses typically cause acute respiratory disease in young children. In
addition, a persistent phase of infection has been observed in which virus may be shed for …

The majority of proteins encoded in the early 3 (E3) region of human subgroup C
adenoviruses function to modulate the host immune response. For example, gp19K, one of …