Osteoprotegerin ameliorates sciatic nerve crush induced bone loss

TA Bateman, CR Dunstan, DL Lacey… - Journal of …, 2001 - Wiley Online Library
This study examines the ability of osteoprotegerin (OPG) to prevent the local bone resorption
caused by sciatic nerve damage. Sixty‐five 18‐week‐old male mice were assigned to one of …

Osteoprotegerin treatment impairs remodeling and apparent material properties of callus tissue without influencing structural fracture strength

M Ulrich-Vinther, TT Andreassen - Calcified tissue international, 2005 - Springer
The influence of osteoprotegerin (OPG) treatment on callus formation, callus tissue structural
strength, apparent material properties, and histology of tibia fractures in rats was …

One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strength

MS Ominsky, M Stolina, X Li, TJ Corbin… - Journal of Bone and …, 2009 - academic.oup.com
RANKL is an essential mediator of bone resorption, and its activity is inhibited by
osteoprotegerin (OPG). Transgenic (Tg) rats were engineered to continuously overexpress …

The effects of osteoprotegerin on the mechanical properties of rat bone

AB Ross, TA Bateman, PJ Kostenuik… - Journal of Materials …, 2001 - Springer
Osteoprotegerin (OPG) is a naturally secreted protein that decreases bone resorption by
inhibiting osteoclast differentiation and activation while promoting osteoclast apoptosis [8]. In …

Osteoclastogenesis inhibitory factor/osteoprotegerin reduced bone loss induced by mechanical unloading

Y Ichinose, H Tanaka, M Inoue, S Mochizuki… - Calcified tissue …, 2004 - Springer
Skeletal unloading resulting from space flight and prolonged immobilization causes bone
loss. Such bone loss ostensibly results from a rapid increase in bone resorption and …

Osteoprotegerin mitigates tail suspension-induced osteopenia

TA Bateman, CR Dunstan, VL Ferguson, DL Lacey… - Bone, 2000 - Elsevier
Osteoprotegerin (OPG) is a recently discovered protein related to the tumor necrosis factor
receptor family. It has been shown to inhibit ovariectomy (ovx)-induced resorption in rats and …

A toxicity profile of osteoprotegerin in the cynomolgus monkey

BB Smith, ME Cosenza, A Mancini… - … journal of toxicology, 2003 - journals.sagepub.com
Osteoprotegerin (OPG) is a novel secreted glycoprotein of the tumor necrosis factor (TNF)
receptor superfamily that acts as an antiresorptive agent inhibiting osteoclast maturation …

Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): a pharmacodynamic and pharmacokinetic analysis in rats

C Capparelli, S Morony, K Warmington… - Journal of Bone and …, 2003 - academic.oup.com
Osteoprotegerin (OPG) is a naturally occurring negative regulator of osteoclast
differentiation, activation, and survival. We created a recombinant form of human OPG …

Changes in osteoprotegerin/RANKL system, bone mineral density, and bone biochemicals markers in patients with recent spinal cord injury

L Maimoun, I Couret, D Mariano-Goulart… - Calcified tissue …, 2005 - Springer
This study analyzed the temporal and regional variations in bone loss and explored bone
cell activities via biochemical markers during an extended follow-up in patients with spinal …

Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats

S Mochizuki, N Fujise, K Higashio, E Tsuda - Journal of bone and mineral …, 2002 - Springer
Rat models of immobilization-induced osteopenia are characterized by uncoupling of bone
metabolism, ie, increased bone resorption and decreased bone formation in trabecular …