The striatum receives massive cortical excitatory inputs and is densely innervated by
dopamine. Striatal projection neurons form either the direct or indirect pathways. Models of …

Striatonigral and striatopallidal neurons form distinct populations of striatal projection
neurons. Their discharge activity is imbalanced after dopaminergic degeneration in …

The basal ganglia (BG) are a collection of interconnected subcortical nuclei that participate
in a great variety of functions, ranging from motor programming and execution to procedural …

The nigrostriatal dopaminergic projection is crucial for the striatal processing of motor
information received from the cortex. Lesion of this pathway in rats causes locomotor …

Classical schemes of basal ganglia organization posit that parkinsonian movement
difficulties presenting after striatal dopamine depletion stem from the disproportionate firing …

Key points• We used optogenetics approach to characterize the short‐term plasticity of
striato‐pallidal (STR–GP) and pallido‐pallidal (GP–GP) GABAergic synapses in rat brain …

The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …

The striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a
diverse array of cellular and synaptic functions that control goal-directed actions and habits …

Highlights•Homeostatic plasticity plays an important role in mitigating striatal
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …

Striatal neurones receive myriad of synaptic inputs originating from different sources.
Massive afferents from all areas of the cortex and the thalamus represent the most important …