Neuronal birth and death are tightly coordinated to establish and maintain properly
functioning neural circuits. Disruption of the equilibrium between neuronal birth and death …

Neuron death and replacement are fundamental components of brain plasticity. Much
remains unknown, however, about the mechanistic interaction between neuron death and …

The adult central nervous system was thought to be very limited in its regenerative potential;
however, the discovery that stem cell populations produce neurons in the adult brain …

The fact that continuous proliferation of stem cells and progenitors, as well as the production
of new neurons, occurs in the adult mammalian central nervous system (CNS) raises several …

As recently as a decade ago, it seemed inconceivable to most neuroscientists that new
neurons could be born routinely in the adult mammalian brain (neurogenesis) and that …

Adult neurogenesis is actively studied in part because of the potential to manipulate
endogenous neural stem and progenitor cells for tissue repair. Although constitutive …

Apoptotic cell death is the leading cause of neuronal loss after neonatal brain injury. Little is
known about the intrinsic capacity of the immature cerebral cortex for replacing dead cells …

After cerebral strokes and traumatic brain injuries (TBIs), there is a striking amount of
neurological recovery in the following months and years, despite often-permanent structural …

It is now evident that the adult vertebrate brain including the human brain is efficiently and
continuously generating new neurons. In the first part we describe the current view of how …

Sex steroids such as androgens and estrogens have trophic effects on the brain and can
ameliorate neurodegeneration, and the withdrawal of circulating steroids induces …