Normal glucose homeostasis is characterized by appropriate insulin secretion and low
HbA1c. Gene expression signatures associated with these two phenotypes could be …

Aims: To identify the key differentially expressed genes (DEGs) in islet and investigate their
potential pathway in the molecular process of type 2 diabetes. Methods: Gene Expression …

Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To
identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic …

Type 1 and 2 diabetes (T1/2D) are complex metabolic diseases caused by absolute or
relative loss of functional β-cell mass, respectively. Both diseases are influenced by multiple …

Dysregulation of gene expression in islets from patients with type 2 diabetes (T2D) might be
causally involved in the development of hyperglycemia, or it could develop as a …

Genetic variation can modulate gene expression, and thereby phenotypic variation and
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …

Objectives Genome-wide association studies (GWAS) have identified> 100 loci
independently contributing to type 2 diabetes (T2D) risk. However, translational implications …

Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain
only 15% of the heritability. In an attempt to identify additional T2D genes, we analyzed …

The spontaneously diabetic Goto-Kakizaki (GK) rat is frequently used as a model for human
type 2 diabetes. Selective loss of glucose-sensitive insulin secretion is an early pathogenetic …

Human pancreatic islets are a major focus of diabetes research due to their key role in
glucose homeostasis and their potential for transplantation in the treatment of type 1 …