Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development
L Wilde, M Roche, M Domingo-Vidal, K Tanson… - Seminars in …, 2017 - Elsevier
abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
The Warburg effect and glucose-derived cancer theranostics
RK Tekade, X Sun - Drug Discovery Today, 2017 - Elsevier
Highlights•Tumor cells increase their metabolic rates as well as glucose uptake to maintain
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …
[HTML][HTML] Emerging metabolic targets in cancer therapy
Y Zhao, H Liu, AI Riker, O Fodstad… - … in bioscience: a …, 2011 - ncbi.nlm.nih.gov
Cancer cells are different from normal cells in their metabolic properties. Normal cells mostly
rely on mitochondrial oxidative phosphorylation to produce energy. In contrast, cancer cells …
rely on mitochondrial oxidative phosphorylation to produce energy. In contrast, cancer cells …
The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism
Compared to normal cells, cancer cells strongly upregulate glucose uptake and glycolysis to
give rise to increased yield of intermediate glycolytic metabolites and the end product …
give rise to increased yield of intermediate glycolytic metabolites and the end product …
[HTML][HTML] The glycolytic switch in tumors: how many players are involved?
L Yu, X Chen, X Sun, L Wang, S Chen - Journal of Cancer, 2017 - ncbi.nlm.nih.gov
Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …
Cancer cell metabolism: implications for therapeutic targets
M Jang, SS Kim, J Lee - Experimental & molecular medicine, 2013 - nature.com
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a
phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in …
phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in …
Tumor cells and cancer-associated fibroblasts: an updated metabolic perspective
G Gentric, F Mechta-Grigoriou - Cancers, 2021 - mdpi.com
Simple Summary Tumors are a complex ecosystem including not only cancer cells, but also
many distinct cell types of the tumor micro-environment. While the Warburg effect assessing …
many distinct cell types of the tumor micro-environment. While the Warburg effect assessing …
Revisiting the Warburg effect with focus on lactate
E Kocianova, V Piatrikova, T Golias - Cancers, 2022 - mdpi.com
Simple Summary Almost a century ago, Nobel Prize laureate Otto Warburg realized that
cancer cells consumed much more glucose than normal cells and also produced large …
cancer cells consumed much more glucose than normal cells and also produced large …
Therapeutic targeting of cancer cell metabolism
Abstract In 1927, Otto Warburg and coworkers reported the increased uptake of glucose and
production of lactate by tumors in vivo as compared with normal tissues. This phenomenon …
production of lactate by tumors in vivo as compared with normal tissues. This phenomenon …
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
L Sun, C Suo, S Li, H Zhang, P Gao - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …