abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …

Highlights•Tumor cells increase their metabolic rates as well as glucose uptake to maintain
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …

Cancer cells are different from normal cells in their metabolic properties. Normal cells mostly
rely on mitochondrial oxidative phosphorylation to produce energy. In contrast, cancer cells …

Compared to normal cells, cancer cells strongly upregulate glucose uptake and glycolysis to
give rise to increased yield of intermediate glycolytic metabolites and the end product …

Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …

Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a
phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in …

Simple Summary Tumors are a complex ecosystem including not only cancer cells, but also
many distinct cell types of the tumor micro-environment. While the Warburg effect assessing …

Simple Summary Almost a century ago, Nobel Prize laureate Otto Warburg realized that
cancer cells consumed much more glucose than normal cells and also produced large …

Abstract In 1927, Otto Warburg and coworkers reported the increased uptake of glucose and
production of lactate by tumors in vivo as compared with normal tissues. This phenomenon …

While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …