Purpose: Perturbation of keratinocyte differentiation by E6/E7 oncoproteins of high-risk
human papillomaviruses that drive oncogenic transformation of cells in squamocolumnar …

The wide range of invasive and noninvasive lesion phenotypes associated with high-risk
human papillomavirus (HR-HPV) infection in cervical cancer (CC) indicates that not only the …

Different rate of development of productive infections (as low grade cervical intraepithelial
neoplasias), or high grade lesions and cervical malignant tumors associated with infections …

Accumulating evidence indicates that the human papillomavirus (HPV) E6 protein plays a
crucial role in the development of cervical cancer. Subpopulations of cells that reside within …

Oct3/4 is a transcription factor involved in maintenance of the pluripotency and self-renewal
of stem cells. The E7 oncoprotein and 17β-estradiol (E 2) are key factors in cervical …

Cancer stem cells (CSC) exhibit high tumorigenic capacity in several tumor models. We
have now determined an extended phenotype for cervical cancer stem cells. Our results …

Viral oncoproteins E6/E7 play key oncogenic role in human papillomavirus (HPV)-mediated
cervical carcinogenesis in conjunction with aberrant activation of cellular signaling events …

Cervical cancer is the fourth most common type of gynecological malignancy to affect
females, worldwide. Although high‑risk human papillomavirus (HR‑HPV) infection is the …

Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women
from developing countries. Similar to other types of cancer, CC is considered to be a …

Abstract Human Papilloma Virus related epithelial cancers have been speculated to derive
from virus-infected tissue stem cells. Stem cells also are thought to provide a reservoir of …