Cannabinoid signaling in cancer

S Das, K Kaul, S Mishra, M Charan… - Recent advances in …, 2019 - Springer
The family of chemical structures that interact with a cannabinoid receptor are broadly
termed cannabinoids. Traditionally known for their psychotropic effects and their use as …

Cannabinoids and cancer: pros and cons of an antitumour strategy

M Bifulco, C Laezza, S Pisanti… - British journal of …, 2006 - Wiley Online Library
In the last two decades, research has dramatically increased the knowledge of cannabinoids
biology and pharmacology. In mammals, compounds with properties similar to active …

Cannabinoid receptor systems: therapeutic targets for tumour intervention

S Jones, J Howl - Expert Opinion on Therapeutic Targets, 2003 - Taylor & Francis
The past decade has witnessed a rapid expansion of our understanding of the biological
roles of cannabinoids and their cognate receptors. It is now certain that Δ9 …

The current state and future perspectives of cannabinoids in cancer biology

P Śledziński, J Zeyland, R Słomski… - Cancer medicine, 2018 - Wiley Online Library
To date, cannabinoids have been allowed in the palliative medicine due to their analgesic
and antiemetic effects, but increasing number of preclinical studies indicates their anticancer …

Receptor-dependent and receptor-independent endocannabinoid signaling: a therapeutic target for regulation of cancer growth

R Van Dross, E Soliman, S Jha, T Johnson… - Life Sciences, 2013 - Elsevier
The endocannabinoid system comprises the G-protein coupled CB1 cannabinoid receptor
(CB1R) and CB2 cannabinoid receptor (CB2R), their endogenous ligands …

Cannabinoids as anticancer drugs: current status of preclinical research

B Hinz, R Ramer - British journal of cancer, 2022 - nature.com
Drugs that target the endocannabinoid system are of interest as pharmacological options to
combat cancer and to improve the life quality of cancer patients. From this perspective …

Endocannabinoids and cancer

G Velasco, C Sánchez, M Guzmán - Endocannabinoids, 2015 - Springer
A large body of evidence shows that cannabinoids, in addition to their well-known palliative
effects on some cancer-associated symptoms, can reduce tumour growth in animal models …

Cannabinoids for cancer treatment: progress and promise

S Sarfaraz, VM Adhami, DN Syed, F Afaq, H Mukhtar - Cancer research, 2008 - AACR
Cannabinoids are a class of pharmacologic compounds that offer potential applications as
antitumor drugs, based on the ability of some members of this class to limit inflammation, cell …

Endocannabinoid system as a regulator of tumor cell malignancy–biological pathways and clinical significance

M Pyszniak, J Tabarkiewicz… - OncoTargets and therapy, 2016 - Taylor & Francis
The endocannabinoid system (ECS) comprises cannabinoid receptors (CBs), endogenous
cannabinoids, and enzymes responsible for their synthesis, transport, and degradation of …

Cannabinoids as prospective anti-cancer drugs: mechanism of action in healthy and cancer cells

Ö Boyacıoğlu, P Korkusuz - … Medicine, Volume 19: Perspectives in Diverse …, 2022 - Springer
Endogenous and exogenous cannabinoids modulate many physiological and pathological
processes by binding classical cannabinoid receptors 1 (CB1) or 2 (CB2) or non …