Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has
been shown to be a powerful strategy within the pharmaceutical industry for increasing …

Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has
been shown to be a powerful strategy within the pharmaceutical industry for increasing …

Although liquid chromatography-tandem mass spectrometry is the gold standard analytical
platform for the quantification of drugs, metabolites, and biomarkers in biological samples, it …

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for
absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial …

Organ toxicity and variable therapeutic efficacy are two main challenges associated with
current drug treatments. 1 In order to optimize drug treatments, it is important to understand …

In pharmaceutical research, understanding the biodistribution, accumulation and
metabolism of drugs in tissue plays a key role during drug discovery and development. In …

Drug efficacy is dependent upon effective and controlled release for delivery to the target
site. The properties of a drug product effecting delivery are carefully manipulated by a variety …

Abstract Background and Purpose Intratumour heterogeneity frequently leads to drug
resistance, which is a major issue in drug discovery. Drug distribution is one of the key …

Mass spectrometry imaging allows direct measurement of the molecular composition of a
sample. It can be used to image the spatial distribution of exogenous drugs and …

Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …