Type-2 ryanodine receptors (RyR2)–the calcium release channels of cardiac sarcoplasmic
reticulum–have a central role in cardiac excitation–contraction coupling. In the heart …

Rationale: Abnormal behavior of the cardiac ryanodine receptor (RyR2) has been linked to
cardiac arrhythmias and heart failure (HF) after myocardial infarction (MI). It has been …

Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because
contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this …

Defective regulation of the cardiac ryanodine receptor (RyR2)/calcium release channel,
required for excitation-contraction coupling in the heart, has been linked to cardiac …

The cardiac ryanodine receptor/calcium release channel (RyR2) on the sarcoplasmic
reticulum (SR) comprises a macromolecular complex that includes a kinase and two …

Abstract Ca 2+-calmodulin kinase II (CaMKII) activation is deleterious in cardiac
ischemia/reperfusion (I/R). Moreover, inhibition of CaMKII-dependent phosphorylations at …

Ca2+ release via type 2 ryanodine receptors (RyR2) regulates cardiac function. Molecular
cloning of human RyR2 identified 2 alternatively spliced variants, comprising 30-and 24-bp …

The ryanodine receptor type 2 (RyR‐2) functions as a Ca 2+‐induced Ca 2+ release (CICR)
channel on intracellular Ca 2+ stores and is distributed in most excitable cells with the …

Background—We previously demonstrated that defective interdomain interaction between N-
terminal (0 to 600) and central regions (2000 to 2500) of ryanodine receptor 2 (RyR2) …

The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …