Background: The DENERHTN trial (Renal Denervation for Hypertension) confirmed the
blood pressure–lowering efficacy of renal denervation added to a standardized stepped …

Background Previous catheter-based renal denervation studies have reported variable
efficacy results. We aimed to evaluate safety and blood pressure response after renal …

Background Renal denervation has been shown to lower blood pressure in the presence of
antihypertensive medications; however, long-term safety and efficacy data from randomised …

Background Previous randomised renal denervation studies did not show consistent efficacy
in reducing blood pressure. The objective of our study was to evaluate the effect of renal …

This ESH update was deemed necessary with the publication of new results of sham-
controlled randomized blinded prospective trials with renal denervation (RDN). Proof of …

Objectives The authors performed an updated meta-analysis of randomized placebo-
controlled trials of renal denervation and specifically compared the effect of renal …

Abstract Background The SPYRAL HTN clinical trial program was initiated with two 80-
patient pilot studies, SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED, which provided …

Abstract Aims The SYMPLICITY HTN-3 randomized, blinded, sham-controlled trial confirmed
the safety of renal denervation (RDN), but did not meet its primary efficacy endpoint. Prior …

The efficacy of renal denervation has been controversial, but recent randomized sham-
controlled trials demonstrated significant blood pressure reductions after renal denervation …

Objective 30 mm Hg drops in office systolic blood pressure are reported in trials of renal
denervation, but ambulatory reductions are much smaller. This disparity is assumed to have …