Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple
sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS …

Nitric oxide (NO) is formed as a consequence of induction of the iNOS enzyme during
inflammatory disorders. To investigate NO production in multiple sclerosis (MS), we …

Nitric oxide is formed from L‐arginine by a family of enzymes: nitric oxide synthase (NOS).
The inducible nitric oxide synthase is activated by cytokines and it has been suggested that …

Nitric oxide (NO) has been implicated as a pathogenic mediator in a variety of central
nervous system (CNS) disease states, including the animal model of multiple sclerosis (MS) …

A cytokine-mediated excessive increase in nitric oxide (NO) by macrophages or glial cells
via an inducible isoform of NO synthase (iNOS) has been proposed to play an important role …

Nitric oxide (. NO) and its reactive derivative peroxynitrite (ONOO7) have been implicated in
the pathogenesis of multiple sclerosis (MS). They are cytotoxic to oligodendrocytes and …

Nitric oxide (NO) production has been associated with disease activity in multiple sclerosis
and experimental autoimmune encephalomyelitis (EAE). This free radical can be …

We used post‐mortem magnetic resonance imaging (MRI) guidance to obtain paired
biopsies from the brains of four patients with clinical definite multiple sclerosis (MS) …

Peroxynitrite, generated by the reaction of nitric oxide (NO) with superoxide at sites of
inflammation, is a strong oxidant capable of damaging tissues and cells. Detection of …

Nitric oxide is a free radical gas, NO, of paramount relevance in biology. The enzymes
responsible for the synthesis of NO from L-arginine in mammalian tissues are known as …