TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma

NL Albert, M Unterrainer, DF Fleischmann… - European journal of …, 2017 - Springer
Objective The 18-kDa mitochondrial translocator protein (TSPO) was reported to be
upregulated in gliomas. 18 F-GE-180 is a novel 3rd generation TSPO receptor ligand with …

Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study

M Unterrainer, DF Fleischmann, C Diekmann… - European journal of …, 2019 - Springer
Background PET represents a valuable tool for glioma imaging. In addition to amino acid
tracers such as 18 F-FET, PET targeting the 18-kDa mitochondrial translocator-protein …

TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlative 18F-GE-180 PET study

M Unterrainer, DF Fleischmann, F Vettermann… - European journal of …, 2020 - Springer
Background The 18-kDa translocator protein (TSPO) is overexpressed in brain tumours and
represents an interesting target for glioma imaging. 18 F-GE-180, a novel TSPO ligand, has …

The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R) PK11195 PET imaging and neuropathology study

Z Su, F Roncaroli, PF Durrenberger… - Journal of Nuclear …, 2015 - Soc Nuclear Med
The 18-kDa mitochondrial translocator protein (TSPO) is upregulated in high-grade
astrocytomas and can be imaged by PET using the selective radiotracer 11C-(R) PK11195 …

[HTML][HTML] TSPO PET signal using [18F]GE180 is associated with survival in recurrent gliomas

S Quach, A Holzgreve, L Kaiser, M Unterrainer… - European Journal of …, 2023 - Springer
Purpose Glioma patients, especially recurrent glioma, suffer from a poor prognosis. While
advances to classify glioma on a molecular level improved prognostication at initial …

[HTML][HTML] The translocator protein ligand [18F]DPA-714 images glioma and activated microglia in vivo

A Winkeler, R Boisgard, AR Awde, A Dubois… - European journal of …, 2012 - Springer
Purpose In recent years there has been an increase in the development of radioligands
targeting the 18-kDa translocator protein (TSPO). TSPO expression is well documented in …

Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH–Wild-Type Glioblastoma

NL Albert, DV Nelwan, DF Fleischmann… - Journal of Nuclear …, 2023 - Soc Nuclear Med
The 18-kDa translocator protein (TSPO) is gaining recognition as a relevant target in
glioblastoma imaging. However, data on the potential prognostic value of TSPO PET …

The potential utility of [68 Ga]Ga-DOTA-FAPI-04 as a novel broad-spectrum oncological and non-oncological imaging agent—comparison with [18F]FDG

L Lan, H Liu, Y Wang, J Deng, D Peng, Y Feng… - European journal of …, 2022 - Springer
Purpose This study aimed to compare the detection performance of [68 Ga] Ga-DOTA-FAPI-
04 and [18F] FDG PET/CT in the patients with various oncological and non-oncological …

Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue

W Rachinger, VM Stoecklein, NA Terpolilli… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Meningiomas are known to express somatostatin receptor 2 (SSTR2). PET using the SSTR2
analog 68Ga-DOTATATE has recently been introduced for imaging of meningiomas …

Dual-tracer PET/CT protocol with [18F]-FDG and [68Ga] Ga-FAPI-46 for cancer imaging: a proof of concept

KS Roth, CA Voltin, L van Heek, S Wegen… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Imaging studies with PET tracers acting as fibroblast activation protein inhibitors (FAPIs)
show promising results that could usefully complement [18F]-FDG in cancer imaging …