Pseudomonas aeruginosa zinc uptake in chelating environment is primarily mediated by the metallophore pseudopaline
S Lhospice, NO Gomez, L Ouerdane, C Brutesco… - Scientific reports, 2017 - nature.com
Metal uptake is vital for all living organisms. In metal scarce conditions a common bacterial
strategy consists in the biosynthesis of metallophores, their export in the extracellular …
strategy consists in the biosynthesis of metallophores, their export in the extracellular …
Growth of Pseudomonas aeruginosa in zinc poor environments is promoted by a nicotianamine‐related metallophore
MC Mastropasqua, M D'Orazio, M Cerasi… - Molecular …, 2017 - Wiley Online Library
Previous studies have suggested that P. aeruginosa possesses redundant zinc uptake
systems. To identify uncharacterized zinc transporters, we analyzed the genome‐wide …
systems. To identify uncharacterized zinc transporters, we analyzed the genome‐wide …
Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen Interface
S Wang, J Cheng, Y Niu, P Li, X Zhang… - Frontiers in Microbiology, 2021 - frontiersin.org
As a structural, catalytic, and signaling component, zinc is necessary for the growth and
development of plants, animals, and microorganisms. Zinc is also essential for the growth of …
development of plants, animals, and microorganisms. Zinc is also essential for the growth of …
The capability of Pseudomonas aeruginosa to recruit zinc under conditions of limited metal availability is affected by inactivation of the ZnuABC transporter
M D'Orazio, MC Mastropasqua, M Cerasi… - Metallomics, 2015 - academic.oup.com
The ability of a large number of bacterial pathogens to multiply in the infected host and
cause disease is dependent on their ability to express high affinity zinc importers. In many …
cause disease is dependent on their ability to express high affinity zinc importers. In many …
The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity
KP Grim, B San Francisco, JN Radin, EB Brazel… - MBio, 2017 - Am Soc Microbiol
During infection, the host sequesters essential nutrients, such as zinc, to combat invading
microbes. Despite the ability of the immune effector protein calprotectin to bind zinc with …
microbes. Despite the ability of the immune effector protein calprotectin to bind zinc with …
Zinc homeostasis in Pseudomonas
V Ducret, D Gonzalez, K Perron - Biometals, 2023 - Springer
In the genus Pseudomonas, zinc homeostasis is mediated by a complete set of import and
export systems, whose expression is precisely controlled by three transcriptional regulators …
export systems, whose expression is precisely controlled by three transcriptional regulators …
The Key Element Role of Metallophores in the Pathogenicity and Virulence of Staphylococcus aureus: A Review
G Ghssein, Z Ezzeddine - Biology, 2022 - mdpi.com
Simple Summary Metallophores, which are secondary metabolites secreted by bacteria,
play an important role in their virulence. The bacterium Staphylococcus aureus produces …
play an important role in their virulence. The bacterium Staphylococcus aureus produces …
Mechanistic insights into staphylopine-mediated metal acquisition
L Song, Y Zhang, W Chen, T Gu… - Proceedings of the …, 2018 - National Acad Sciences
Metal acquisition is vital to pathogens for successful infection within hosts. Staphylopine
(StP), a broad-spectrum metallophore biosynthesized by the major human pathogen …
(StP), a broad-spectrum metallophore biosynthesized by the major human pathogen …
Efficient zinc uptake is critical for the ability of Pseudomonas aeruginosa to express virulence traits and colonize the human lung
MC Mastropasqua, I Lamont, LW Martin… - Journal of Trace …, 2018 - Elsevier
We have recently shown that Pseudomonas aeruginosa, an opportunistic pathogen that
chronically infects the lungs of patients with cystic fibrosis (CF) and other forms of lung …
chronically infects the lungs of patients with cystic fibrosis (CF) and other forms of lung …
A Review of Pseudomonas aeruginosa Metallophores: Pyoverdine, Pyochelin and Pseudopaline
G Ghssein, Z Ezzeddine - Biology, 2022 - mdpi.com
Simple Summary The human pathogen Pseudomonas aeruginosa (P. aeruginosa) causes
several infections, both acute and chronic, mainly in hosts with compromised immunity and …
several infections, both acute and chronic, mainly in hosts with compromised immunity and …
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