532 Circulation Research February 19, 2016 unresolved questions and to exploit the newer
discoveries that have opened unanticipated horizons of understanding and raised novel …

Atherosclerosis is a complex and heritable disease involving multiple cell types and the
interactions of many different molecular pathways. The genetic and molecular mechanisms …

Recent rapid advances in genomic tools and techniques hold great promise for transforming
the practice of cardiovascular medicine. Resources including the Human Genome Project …

Scientific understanding of atherogenesis is constantly developing. From Virchow's
observations 160 years ago we now recognize the endothelial response to injury as …

Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …

In this review, we summarize current knowledge on the genetics of coronary artery disease,
based on 10 years of genome-wide association studies. The discoveries began with …

Many cardiovascular diseases are facilitated by strong inheritance. For example, large-scale
genetic studies identified hundreds of genomic loci that affect the risk of coronary artery …

OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Atherosclerosis causes myocardial infarction, ischaemic cardiomyopathy, many ischaemic
strokes and jeopardized limbs. Despite enormous progress, atherosclerosis has become the …

Genome-wide association studies (GWAS) from the past several years have provided the
first unbiased evidence of the genes contributing to common cardiovascular disease traits in …