[HTML][HTML] Development and characterization of a Wee1 kinase degrader
The G1/S cell cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells
reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates …
reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates …
[HTML][HTML] Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases
MC Aublette, TA Harrison, EJ Thorpe… - Bioorganic & Medicinal …, 2022 - Elsevier
Abstract The Ser/Thr protein kinase Wee1 plays a regulatory role at the G 2/M checkpoint by
phosphorylating CDK1 when DNA is damaged to allow time for DNA to repair, disruption of …
phosphorylating CDK1 when DNA is damaged to allow time for DNA to repair, disruption of …
Targeting WEE1 kinase in cancer
CJ Matheson, DS Backos, P Reigan - Trends in pharmacological sciences, 2016 - cell.com
WEE1 kinase plays a crucial role in the G2–M cell-cycle checkpoint arrest for DNA repair
before mitotic entry. Normal cells repair damaged DNA during G1 arrest; however, cancer …
before mitotic entry. Normal cells repair damaged DNA during G1 arrest; however, cancer …
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
H Hirai, Y Iwasawa, M Okada, T Arai, T Nishibata… - Molecular cancer …, 2009 - AACR
Wee1 is a tyrosine kinase that phosphorylates and inactivates CDC2 and is involved in G2
checkpoint signaling. Because p53 is a key regulator in the G1 checkpoint, p53-deficient …
checkpoint signaling. Because p53 is a key regulator in the G1 checkpoint, p53-deficient …
Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy
AD Guertin, J Li, Y Liu, MS Hurd, AG Schuller… - Molecular cancer …, 2013 - AACR
Inhibition of the DNA damage checkpoint kinase WEE1 potentiates genotoxic
chemotherapies by abrogating cell-cycle arrest and proper DNA repair. However, WEE1 is …
chemotherapies by abrogating cell-cycle arrest and proper DNA repair. However, WEE1 is …
Wee1 kinase as a target for cancer therapy
K Do, JH Doroshow, S Kummar - Cell cycle, 2013 - Taylor & Francis
Wee1, a protein kinase, regulates the G2 checkpoint in response to DNA damage.
Preclinical studies have elucidated the role of wee1 in DNA damage repair and the …
Preclinical studies have elucidated the role of wee1 in DNA damage repair and the …
Molecular pathways: targeting the protein kinase Wee1 in cancer
JJJ Geenen, JHM Schellens - Clinical Cancer Research, 2017 - AACR
Wee1 is a protein kinase that regulates the G2 checkpoint and prevents entry into mitosis in
response to DNA damage. Cyclin-dependent kinases (CDK) are a family of 14 …
response to DNA damage. Cyclin-dependent kinases (CDK) are a family of 14 …
MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells
JM Kreahling, JY Gemmer, D Reed, D Letson… - Molecular cancer …, 2012 - AACR
Wee1 is a critical component of the G2–M cell-cycle checkpoint control and mediates cell-
cycle arrest by regulating the phosphorylation of CDC2. Inhibition of Wee1 by a selective …
cycle arrest by regulating the phosphorylation of CDC2. Inhibition of Wee1 by a selective …
Synthetic and medicinal chemistry approaches toward WEE1 kinase inhibitors and its degraders
WEE1 is a checkpoint kinase critical for mitotic events, especially in cell maturation and DNA
repair. Most cancer cells' progression and survival are linked with elevated levels of WEE1 …
repair. Most cancer cells' progression and survival are linked with elevated levels of WEE1 …
WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe
PC De Witt Hamer, SE Mir, D Noske… - Clinical cancer …, 2011 - AACR
WEE1 kinase is a key molecule in maintaining G2–cell-cycle checkpoint arrest for premitotic
DNA repair. Whereas normal cells repair damaged DNA during G1-arrest, cancer cells often …
DNA repair. Whereas normal cells repair damaged DNA during G1-arrest, cancer cells often …