A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

G Kar, M Berg, O Carpaij, K Polanski, L Simon… - 2019 - europepmc.org
Human lungs enable efficient gas exchange, and form an interface with the environment
which depends on mucosal immunity for protection against infectious agents. Tightly …

[PDF][PDF] A cellular census of healthy lung and asthmatic airway wall identifies novel cell states 2 in health and disease 3

W Timens, I Angelidis, M Strunz, GH Koppelman… - core.ac.uk
Human lungs enable efficient gas exchange, and form an interface with the environment 53
which depends on mucosal immunity for protection against infectious agents. Tightly 54 …

A cellular census of human lungs identifies novel cell states in health and in asthma

FA Vieira Braga, G Kar, M Berg, OA Carpaij… - Nature medicine, 2019 - nature.com
Human lungs enable efficient gas exchange and form an interface with the environment,
which depends on mucosal immunity for protection against infectious agents. Tightly …

Single Cell Transcriptomics Reveals the Cellular and Molecular Diversity of the Human Tracheal Airway Epithelium in Smokers and Non-Smokers

K Goldfarbmuren, ND Jackson, N Dyjack… - … LANDSCAPE OF THE …, 2019 - atsjournals.org
RATIONALE The human airway epithelium serves as the crucial front line for our interaction
with the airborne environment, from vital gases to harmful microbes, toxins and particulates …

A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

E Madissoon, AJ Oliver, V Kleshchevnikov… - Nature Genetics, 2023 - nature.com
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

Regulation of immune responses by the airway epithelial cell landscape

RJ Hewitt, CM Lloyd - Nature Reviews Immunology, 2021 - nature.com
The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

Decoding the epithelial-T helper cell signalling axis in human asthmatic airways one cell at a time

A Oliver, E Madissoon, W Sungnak, M Berg, R Kapuge… - 2023 - Eur Respiratory Soc
Chronic inflammation is a driver of many lung and airways diseases. A key component of
airway inflammation is the cross-talk between the epithelial cells and resident immune cells …

High Resolution Evaluation of Human Airway Cell Diversity Towards Understanding the Cellular Composition and Function of the Distal Human Airways

MC Basil, W Zacharias, J Katzen, J Carl, S Li… - The FASEB …, 2019 - Wiley Online Library
The mammalian lung is a complex organ comprised of epithelial cells, supporting stroma,
and capillaries, which combine to allow the lung to perform its principle function of gas …

[HTML][HTML] A spatial multi-omics atlas of the human lung reveals a novel gland-associated immune niche

K Meyer, E Madissoon, A Oliver, V Kleshchevnikov… - 2022 - europepmc.org
To (re) defìne tissue architecture of the lung and airways at the cellular and molecular level,
we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-omic …

Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia

NA Barrett, AK Shalek - Journal of Allergy and Clinical Immunology, 2019 - jacionline.org
Advances in single-cell RNA sequencing (scRNA-seq) allow the characterization of cellular
states across human tissues with unprecedented granularity, creating opportunities to …