Huntington disease (HD) is an adult onset neurodegenerative disorder that predominantly
affects the striatum and cortex despite ubiquitous expression of mutant huntingtin (htt). Here …

A number of mouse models expressing mutant huntingtin (htt) with an expanded
polyglutamine (polyQ) domain are useful for studying the pathogenesis of Huntington's …

Huntington disease (HD) is caused by an expansion of the polyglutamine (polyQ) repeat (>
37Q) in huntingtin (htt), and age of onset is inversely correlated with the length of the polyQ …

Huntington's disease (HD) mouse models that express N-terminal huntingtin fragments
show rapid disease progression and have been used for developing therapeutics. However …

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an
expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in …

Huntington disease (HD) is an adult-onset neurodegenerative disease caused by a toxic
gain of function in the huntingtin (htt) protein. The contribution of wild-type htt function to the …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder
characterized behaviorally by chorea, incoordination, and shortened lifespan and …

Recent studies have identified impairments in neural induction and in striatal and cortical
neurogenesis in Huntington's disease (HD) knock-in mouse models and associated …

Huntington disease (HD) is a devastating neuropsychiatric disease caused by expansion of
a trinucleotide repeat (CAG) in the HD gene. Neuropathological changes include the …

Huntington's disease results from a polyglutamine expansion in the N-terminal region of
huntingtin (htt). This abnormality causes protein aggregation and leads to neurotoxicity …