Bioinspired multivalent DNA network for capture and release of cells

W Zhao, CH Cui, S Bose, D Guo… - Proceedings of the …, 2012 - National Acad Sciences
Capture and isolation of flowing cells and particulates from body fluids has enormous
implications in diagnosis, monitoring, and drug testing, yet monovalent adhesion molecules …

Multivalent DNA nanospheres for enhanced capture of cancer cells in microfluidic devices

W Sheng, T Chen, W Tan, ZH Fan - ACS nano, 2013 - ACS Publications
Isolation of circulating tumor cells (CTCs) from peripheral blood or cancer cells from bone
marrow has significant applications in cancer diagnosis, therapy monitoring, and drug …

DNA nanolithography enables a highly ordered recognition interface in a microfluidic chip for the efficient capture and release of circulating tumor cells

J Zhang, B Lin, L Wu, M Huang, X Li… - Angewandte …, 2020 - Wiley Online Library
Microfluidic chips with nano‐scale structures have shown great potential, but the fabrication
and cost issues restrict their application. Herein, we propose a conceptually new “DNA …

Encapsulation and release of living tumor cells using hydrogels with the hybridization chain reaction

D Ye, M Li, T Zhai, P Song, L Song, H Wang, X Mao… - Nature …, 2020 - nature.com
Circulating tumor cells (CTCs) enable noninvasive liquid biopsy and identification of cancer.
Various approaches exist for the capture and release of CTCs, including microfluidic …

Aptamer-enabled efficient isolation of cancer cells from whole blood using a microfluidic device

W Sheng, T Chen, R Kamath, X Xiong, W Tan… - Analytical …, 2012 - ACS Publications
Circulating tumor cells (CTC) in the peripheral blood could provide important information for
diagnosis of cancer metastasis and monitoring treatment progress. However, CTC are …

Accurate isolation of circulating tumor cells via a heterovalent DNA framework recognition element-functionalized microfluidic chip

Y Liu, Z Lin, Z Zheng, Y Zhang, L Shui - ACS sensors, 2022 - ACS Publications
Detection of circulating tumor cells (CTCs) has provided a noninvasive and efficient
approach for early diagnosis, treatment, and prognosis of cancer. However, efficient capture …

T lymphocyte-captured DNA network for localized immunotherapy

C Yao, C Zhu, J Tang, J Ou, R Zhang… - Journal of the American …, 2021 - ACS Publications
The efficient isolation of immune cells with high purity and low cell damage is important for
immunotherapy and remains highly challenging. We herein report a cell capture DNA …

Double rolling circle amplification generates physically cross-linked DNA network for stem cell fishing

C Yao, H Tang, W Wu, J Tang, W Guo… - Journal of the …, 2020 - ACS Publications
Stem cells have been widely studied in cell biology and utilized in cell-based therapies, and
fishing stem cells from marrow is highly challenging due to the ultralow content. Herein, a …

Aptamer-based microfluidic device for enrichment, sorting, and detection of multiple cancer cells

Y Xu, JA Phillips, J Yan, Q Li, ZH Fan… - Analytical chemistry, 2009 - ACS Publications
The ability to diagnose cancer based on the detection of rare cancer cells in blood or other
bodily fluids is a significant challenge. To address this challenge, we have developed a …

Enrichment of cancer cells using aptamers immobilized on a microfluidic channel

JA Phillips, Y Xu, Z Xia, ZH Fan, W Tan - Analytical chemistry, 2009 - ACS Publications
This work describes the development and investigation of an aptamer modified microfluidic
device that captures rare cells to achieve a rapid assay without pretreatment of cells. To …