Gram-negative bacteria utilize specialized machinery to translocate drugs and protein toxins
across the inner and outer membranes, consisting of a tripartite complex composed of an …

Periplasmic membrane fusion proteins (MFPs) are essential components of the type I protein
secretion systems and drug efflux pumps in Gram‐negative bacteria. Previous studies …

Summary Escherichia coli MacAB‐TolC is a tripartite macrolide efflux transporter driven by
hydrolysis of ATP. In this complex, MacA is the periplasmic membrane fusion protein that …

MacB is a founding member of the M acrolide E xporter family of transporters belonging to
the ATP‐B inding C assette superfamily. These proteins are broadly represented in …

MacB is an ABC‐type membrane protein that exports only macrolide compounds containing
14‐and 15‐membered lactones, cooperating with a membrane fusion protein, MacA, and a …

Abstract The MacA–MacB–TolC tripartite complex is a transmembrane machine that spans
both plasma membrane and outer membrane and actively extrudes substrates, including …

Abstract The MacA–MacB–TolC assembly of Escherichia coli is a transmembrane machine
that spans the cell envelope and actively extrudes substrates, including macrolide antibiotics …

In the Escherichia coli genome, five putative open reading frame (ORF) clusters, mdlAB,
ybjYZ, yddA, yojHI, and yhiH, have been assumed to be possible genes for ABC drug efflux …

MacB is a noncanonic ABC-type transporter within Gram-negative bacteria, which is
responsible both for the efflux of macrolide antibiotics and for the secretion of heat-stable …

ABSTRACT The Escherichia coli MacAB-TolC transporter has been implicated in efflux of
macrolide antibiotics and secretion of enterotoxin STII. In this study, we found that purified …