The normal architecture and biologic function of the kidney depends on an integrated
network of cellular and extracellular matrix interactions. The extracellular matrix, in addition …

Chronic kidney disease at a certain advanced stage inevitably progresses to end stage
renal failure characterized by the progressing loss of nephrons accompanied by the …

The progression of chronic renal failure is characterised histologically by
glomerulosclerosis, tubulointerstitial fibrosis and vascular sclerosis. Recent research has …

Interstitial fibrosis is a common feature of chronic kidney disease, regardless of the etiology
of the primary renal syndrome. Moreover, interstitial fibrosis is the strongest morphologic …

Tubulointerstitial fibrosis invariably accompanies the course of chronic renal failure towards
end-stage renal disease. Tubular epithelial cells, the predominant cell type in the …

Tubulointerstitial damage and progression of renal failure. The present work reviews the
mechanisms and close association between glomerular and tubular damage and its …

Connective tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic
process associated with both physiological responses, such as wound healing, and …

The relentless progression of many renal diseases to end-stage renal failure after an
apparently transient initial insult remains an enigma that continues to fascinate …

Tubulointerstitial injury is an invariant finding in the chronically diseased kidney, irrespective
of the type of disease or the compartment in which the disease originates. Such histologic …

Progressive renal failure results from a triad of glomerulosclerosis, tubulointerstitial fibrosis
and vascular sclerosis. The mechanisms by which tubules are injured, and by which the …