Protein aggregation in brainstem nuclei is thought to occur in the early stages of Alzheimer's
disease (AD), but its specific role in driving prodromal symptoms and disease progression is …

Alzheimer's disease (AD) is a progressive degenerative disorder that results in a severe loss
of brain cells and irreversible cognitive decline. Memory problems are the most recognized …

Alzheimer's disease (AD) poses an ever-increasing public health concern as the population
ages, affecting more than 6 million Americans. AD patients present with mood and sleep …

Aims Hyperphosphorylated tau neuronal cytoplasmic inclusions (ht‐NCI) are the best
protein correlate of clinical decline in Alzheimer's disease (AD). Qualitative evidence …

Reduced bone mineral density (BMD) and its clinical sequelae, osteoporosis, occur at a
much greater rate in patients with Alzheimer's disease (AD), often emerging early in the …

Alzheimer's disease is characterized by accumulation of amyloid plaques and tau
aggregates in several cortical brain regions. Tau phosphorylation causes formation of …

J. Attems, A. Thomas and K. Jellinger (2012) Neuropathology and Applied Neurobiology38,
582–590 Correlations between cortical and subcortical tau pathology Aim: Recent studies …

At present, half a million Canadians are suffering from dementia and dementia related
disorders costing approximately $11 billion annually and putting additional strain on a …

Alzheimer's disease (AD) poses an ever-increasing public health concern as the population
ages, affecting more than 6 million Americans. AD patients present with mood and sleep …

Widespread cortical accumulation of misfolded pathological tau proteins (ptau) in the form of
paired helical filaments is a major hallmark of Alzheimer's disease. Subcellular localization …