Evidence points at microenvironment and cell functional features rather than cell
polarization or differentiation as determinants of pathogenesis. In terms of therapeutic …

Introduction: Sarcoidosis is a multi-systemic granulomatous disease of unknown aetiology.
Ethnicity and environmental factors may influence disease incidence, phenotype and …

Sarcoidosis continues to be a disease of research interest because of its complicated
immune mechanisms and elusive etiology. So far, it has been established that …

Sarcoidosis is a granulomatous multiorgan disease, thought to result from exposure to yet
unidentified antigens in genetically susceptible individuals. The exaggerated inflammatory …

The immunopathogenesis of sarcoidosis remains unclear. This failure in understanding has
been clinically impactful, as it has impeded the accurate diagnosis, treatment, and …

Sarcoidosis is a multisystem granulomatous disorder invariably affecting the lungs. It is a
disease with noteworthy variations in clinical manifestation and disease outcome and has …

Despite more than a century of research, the causative agent (s) in sarcoidosis, a
heterogeneous granulomatous disorder mainly affecting the lungs, remain (s) elusive …

Our understanding of the immunopathogenesis of sarcoidosis has been advanced by
studies of bronchoalveolar lavage cells. Activated macrophages and T-cells have been …

Introduction: The pathogenesis of sarcoidosis is not yet completely understood, although in
recent years our knowledge has made considerable progress. Areas covered: This review …

Research over the past decade has advanced our understanding of the pathogenesis of
sarcoidosis and provided new insights into potential causes of this disease. It is important to …