The human Toll signaling pathway: divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor–associated factor 6 (TRAF6)
The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the
interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of …
interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of …
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
R Medzhitov, P Preston-Hurlburt, E Kopp, A Stadlen… - Molecular cell, 1998 - cell.com
The Toll-mediated signaling cascade using the NF-κB pathway has been shown to be
essential for immune responses in adult Drosophila, and we recently reported that a human …
essential for immune responses in adult Drosophila, and we recently reported that a human …
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense
A Dunne, LAJ O'Neill - Science's STKE, 2003 - science.org
The signal transduction pathways activated by the proinflammatory cytokine interleukin-1 (IL-
1) have been the focus of much attention because of the important role that IL-1 plays in …
1) have been the focus of much attention because of the important role that IL-1 plays in …
Cloning and characterization of two toll/interleukin-1 receptor–like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans
PM Chaudhary, C Ferguson, V Nguyen… - Blood, The Journal …, 1998 - ashpublications.org
Remarkable structural and functional similarities exist between the Drosophila
Toll/Cactus/Dorsal signaling pathway and the mammalian cytokine-mediated interleukin-1 …
Toll/Cactus/Dorsal signaling pathway and the mammalian cytokine-mediated interleukin-1 …
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense
LAJ O'Neill - Science's STKE, 2000 - science.org
The signal transduction pathways activated by the proinflammatory cytokine interleukin-1 (IL-
1) have been the focus of much attention because of the important role that IL-1 plays in …
1) have been the focus of much attention because of the important role that IL-1 plays in …
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide
A Didierlaurent, B Brissoni, D Velin… - … and cellular biology, 2006 - Am Soc Microbiol
Abstract Activation of interleukin-1 (IL-1) receptor (IL-1R), Toll-like receptor 2 (TLR2), and
TLR4 triggers NF-κB and mitogen-activated protein kinase (MAPK)-dependent signaling …
TLR4 triggers NF-κB and mitogen-activated protein kinase (MAPK)-dependent signaling …
Interleukin-1/Toll receptor family members: receptor structure and signal transduction pathways
JM Daun, MJ Fenton - Journal of Interferon & Cytokine Research, 2000 - liebertpub.com
Interleukin-1 (IL-1) is a central mediator of the inflammatory response. It plays a role in both
systemic and local immune responses to invading microbes. There are two receptors (IL-1RI …
systemic and local immune responses to invading microbes. There are two receptors (IL-1RI …
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor …
Z Jiang, HJ Johnson, H Nie, J Qin, TA Bird… - Journal of Biological …, 2003 - ASBMB
The signaling pathway downstream of the mammalian interleukin-1 receptor (IL-1R)/Toll-like
receptor (TLR) is evolutionally conserved with that mediated by theDrosophila Toll protein …
receptor (TLR) is evolutionally conserved with that mediated by theDrosophila Toll protein …
[HTML][HTML] Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family
MU Martin, H Wesche - Biochimica et Biophysica Acta (BBA)-Molecular …, 2002 - Elsevier
The Toll/interleukin-1 (IL-1) receptor (TIR) family comprises two groups of transmembrane
proteins, which share functional and structural properties. The members of the IL-1 receptor …
proteins, which share functional and structural properties. The members of the IL-1 receptor …
Toll receptors: an expanding role in our understanding of human disease
JM Schuster, PS Nelson - Journal of Leukocyte Biology, 2000 - academic.oup.com
Toll receptor proteins in Drosophila are involved in establishing the dorsal-ventral axis in
embryogenesis as well as participating in the innate immune response to invading …
embryogenesis as well as participating in the innate immune response to invading …