SOCS-1 is a critical regulator of multiple signaling pathways, including those activated by
cytokines that regulate Ig H chain class switching to IgE. Analysis of mice with mutations in …

Suppressor of cytokine signaling (SOCS) 1 is an essential physiologic regulator of the IFN-γ
signaling that is crucial to lead appropriate immune responses, and impaired IFN-γ …

Suppressor of cytokine signalling (SOCS) proteins are inducible feedback inhibitors of
Janus kinase (JAK) and signal transducers and activators of transcription signalling (STAT) …

Background The SOCS proteins act as suppressors of cytokine signaling by impeding
certain signaling pathways. SOCS5, a constituent of the SOCS family, has been associated …

Suppressors of cytokine signalling (SOCS) proteins play important roles in the negative
regulation of cytokine signal. We first searched for polymorphisms in SOCS‐1, SOCS‐3 and …

The immunopathological hallmark of allergic diseases is elevated total and allergen specific
serum IgE levels along with inflammation. This inflammation results from the activation of a …

In a systematic analysis of global gene-expression patterns, we found that SOCS3
messenger RNA was significantly more highly expressed in skin from patients with atopic …

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Cell–cell communication depends on cytokine and growth factor network. Bound to their
receptors on the surface of target cell, these glycoproteins initiate a range of intracellular …

Background The molecular determinants of the severity and persistence of allergic asthma
remain poorly understood. Suppressor of cytokine signalling 1 (SOCS1) is a negative …