RGD peptides released from βig-h3, a TGF-β-induced cell-adhesive molecule, mediate apoptosis
Abstract βig-h3 is a transforming growth factor-β (TGF-β)-induced cell-adhesive molecule
and has an RGD sequence at its C-terminus. A previous report suggested that βig-h3 …
and has an RGD sequence at its C-terminus. A previous report suggested that βig-h3 …
βig-h3: A Transforming Growth Factor-β-Responsive Gene Encoding a Secreted Protein That Inhibits Cell Attachment In Vitro and Suppresses the Growth of CHO …
J SKONIER, K BENNETT, V ROTHWELL… - DNA and cell …, 1994 - liebertpub.com
ABSTRACT βig-h3 is a novel gene first discovered by differential screening of a cDNA
library made from A549 human lung adenocarcinoma cells treated with transforming growth …
library made from A549 human lung adenocarcinoma cells treated with transforming growth …
RGD peptides induce apoptosis by direct caspase-3 activation
CD Buckley, D Pilling, NV Henriquez, G Parsonage… - Nature, 1999 - nature.com
Synthetic peptides containing the arginine–glycine–aspartate (RGD) motif have been used
extensively as inhibitors of integrin–ligand interactions in studies of cell adhesion, migration …
extensively as inhibitors of integrin–ligand interactions in studies of cell adhesion, migration …
G protein βγ subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes
MR Seo, MJ Lee, JH Heo, YI Lee, Y Kim, SY Kim… - Journal of Biological …, 2007 - ASBMB
UV radiation induces various cellular responses by regulating the activity of many UV-
responsive enzymes, including MAPKs. The βγ subunit of the heterotrimeric GTP-binding …
responsive enzymes, including MAPKs. The βγ subunit of the heterotrimeric GTP-binding …
Intracellular targets of RGDS peptide in melanoma cells
MS Aguzzi, P Fortugno, C Giampietri, G Ragone… - Molecular cancer, 2010 - Springer
Background RGD-motif acts as a specific integrins-ligand and regulates a variety of cell-
functions via extracellular action affecting cell-adhesion properties. However, increasing …
functions via extracellular action affecting cell-adhesion properties. However, increasing …
RGD peptide-induced apoptosis in human leukemia HL-60 cells requires caspase-3 activation
CD Anuradha, S Kanno, S Hirano - Cell biology and toxicology, 2000 - Springer
RGD motif-containing peptides have been used in various studies of cell adhesion and
growth. We report that RGD triggered apoptosis at a concentration of 1 mmol/L, whereas …
growth. We report that RGD triggered apoptosis at a concentration of 1 mmol/L, whereas …
Transforming growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): a matrix protein with dual functions in ovarian cancer
Transforming growth factor-beta-induced protein (TGFBI, also known as βig-H3 and
keratoepithelin) is an extracellular matrix protein that plays a role in a wide range of …
keratoepithelin) is an extracellular matrix protein that plays a role in a wide range of …
Transforming growth factor-β-inducible gene-h3 (βig-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of α6β4 integrin
MO Kim, SJ Yun, IS Kim, S Sohn, EH Lee - Neuroscience letters, 2003 - Elsevier
βig-h3 is a secretory protein that is induced by transforming growth factor (TGF)-β. We have
recently found that βig-h3 expression is induced in cultured astrocytes by TGF-β1 and in rat …
recently found that βig-h3 expression is induced in cultured astrocytes by TGF-β1 and in rat …
Loss of Betaig‐h3 protein is frequent in primary lung carcinoma and related to tumorigenic phenotype in lung cancer cells
Y Zhao, M El‐Gabry, TK Hei - … with the University of Texas MD …, 2006 - Wiley Online Library
Betaig‐h3 as a secreted protein induced by transforming growth factor‐β has been
suggested to modulate cell adhesion and tumor formation. Although we have previously …
suggested to modulate cell adhesion and tumor formation. Although we have previously …
RGD peptide-induced cell death of chondrocytes and synovial cells
K Matsuki, T Sasho, K Nakagawa, M Tahara… - Journal of Orthopaedic …, 2008 - Elsevier
Background Small peptides including the Arg-Gly-Asp (RGD) motif have been used in
studies on cell-extracellular matrix (ECM) attachment due to their ability to disturb integrin …
studies on cell-extracellular matrix (ECM) attachment due to their ability to disturb integrin …
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