The thymus has two important roles in controlling the specificity of T lymphocytes. First, T
cells differentiating in the thymus are rendered tolerant of 'self'antigens, particularly antigens …

THE thymus positively selects thymocytes that bear T-cell receptors which recognize antigen
presented by self major histocompatibility complex (MHC) proteins1, 2. Positive selection is …

Differentiation of bone marrow derived precursors into mature T cells takes place in the
thymus. During differentiation, T cells develop the receptor repertoire which allows them to …

T-cell immunocompetence and diversity are thought to be generated in the thymus1, 2. This
view is based on the findings that (1) T-cell ontogeny is thymus dependent3, 4,(2) the major …

Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II
molecules encoded by the major histocompatibility complex (MHC) by virtue of the …

SUCCESSFUL intrathymic differentiation of αβTCR+ T cells depends on positive selection of
CD4+ CD8+ thymocytes by thymic major histocompatibility complex (MHC) molecules1–9 …

CELL mediated immune reactions in mice involving cytotoxic thymus derived lymphocytes
have two important features; they are antigen-specific1 and the structures coded for by the …

T LYMPHOCYTES differentiate in the thymus, where functionally immature, CD4+ CD8+
(double positive) thymocytes develop into functionally mature CD4+ helper cells and CD8+ …

Foreign tissues grafted into healthy recipients are usually rejected by the hosts' immune
system largely by means of major histocompatibility complex (MHC) products expressed on …

The mature T-cell antigen receptor repertoire is characterized by lack of reactivity to self-
components as well as by preferential reactivity to foreign antigens in the context of …