Cell immortalization has been considered for a long time as a classic hallmark of cancer
cells. Besides telomerase reactivation, such immortalization could be due to telomere …

High telomerase activity is detected in nearly all human cancers but most human cells are
devoid of telomerase activity. There is well-documented evidence that reactivation of …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Human telomeres function as a protective structure capping both ends of the chromosome.
They are composed of long, repetitive sequences of TTAGGG, associated with a variety of …

Telomerase regulation and telomere shortening act as a strong tumor suppressor
mechanism in human somatic cells. Point mutations in the promoter of telomerase reverse …

Telomerase activity and telomere elongation are essential conditions for the unlimited
proliferation of neoplastic cells. Point mutations in the core promoter region of the …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Nature recruited telomerase to compensate for the incomplete replication of chromosomal
ends (telomeres). In higher organisms, telomeres are eroded at each cell division. Cancer …

Telomere shortening at chromosomal ends due to the constraints of the DNA replication
process acts as a tumor suppressor by restricting the replicative potential in primary cells …

Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple
rounds of replications. During tumorigenesis, cells have to acquire telomere DNA …