Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer

MA Clarke, P Luhn, JC Gage, C Bodelon… - … journal of cancer, 2017 - Wiley Online Library
Human papillomavirus (HPV) testing has been recently introduced as an alternative to
cytology for cervical cancer screening. However, since most HPV infections clear without …

Human papillomavirus DNA methylation as a biomarker for cervical precancer: consistency across 12 genotypes and potential impact on management of HPV-positive …

MA Clarke, A Gradissimo, M Schiffman, J Lam… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Human papillomavirus (HPV) DNA methylation testing is a promising
triage option for women testing HPV positive during cervical cancer screening. However, the …

A four‐gene methylation marker panel as triage test in high‐risk human papillomavirus positive patients

JJH Eijsink, A Lendvai, V Deregowski… - … journal of cancer, 2012 - Wiley Online Library
Cervical neoplasia‐specific biomarkers, eg DNA methylation markers, with high sensitivity
and specificity are urgently needed to improve current population‐based screening on (pre) …

DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort

RW van Leeuwen, A Oštrbenk, M Poljak… - … Journal of Cancer, 2019 - Wiley Online Library
Objective triage strategies are required to prevent unnecessary referrals for colposcopy in
population‐based screening programs using primary high‐risk human papillomavirus …

Quantitative measurement of Human Papillomavirus type 16 L1/L2 DNA methylation correlates with cervical disease grade

D Bryant, A Tristram, T Liloglou, S Hibbitts… - Journal of Clinical …, 2014 - Elsevier
Abstract Background Persistent infection with Human Papillomavirus (HPV) type 16 causes
the majority of cervical cancers. Genital HPV infection is very common, but neoplastic …

[HTML][HTML] DNA methylation as a triage tool for cervical cancer screening–A meeting report

FR Burdier, B Nedjai, RDM Steenbergen… - Preventive medicine …, 2024 - Elsevier
Introduction DNA methylation is proposed as a novel biomarker able to monitor molecular
events in human papillomavirus (HPV) infection pathophysiology, enabling the distinction …

A DNA methylation classifier of cervical precancer based on human papillomavirus and human genes

AR Brentnall, N Vasiljević… - … journal of cancer, 2014 - Wiley Online Library
Testing for high‐risk (hr) types of human papillomavirus (HPV) is highly sensitive as a
screening test of high‐grade cervical intraepithelial neoplastic (CIN2/3) disease, the …

A promising DNA methylation signature for the triage of high-risk human papillomavirus DNA-positive women

A Hansel, D Steinbach, C Greinke, M Schmitz, J Eiselt… - PloS one, 2014 - journals.plos.org
High-risk human papillomavirus (hrHPV)-DNA testing is frequently performed parallel to
cytology for the detection of high-grade dysplasia and cervical cancer particularly in women …

[HTML][HTML] Credentialing of DNA methylation assays for human genes as diagnostic biomarkers of cervical intraepithelial neoplasia in high-risk HPV positive women

N Vasiljević, D Scibior-Bentkowska, AR Brentnall… - Gynecologic …, 2014 - Elsevier
Objective Testing for high risk human papillomavirus (HR-HPV) is increasing; however due
to limitations in specificity there remains a need for better triage tests. Research efforts have …

Human papillomavirus DNA methylation as a potential biomarker for cervical cancer

MA Clarke, N Wentzensen, L Mirabello, A Ghosh… - … , biomarkers & prevention, 2012 - AACR
Sexually transmitted carcinogenic human papillomavirus (HPV) infections are extraordinarily
prevalent worldwide. However, most incident HPV infections clear within a few years …