Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice
EL Clinkenbeard, EG Farrow… - Journal of Bone and …, 2014 - academic.oup.com
ABSTRACT Fibroblast growth factor 23 (FGF23) gain of function mutations can lead to
autosomal dominant hypophosphatemic rickets (ADHR) disease onset at birth, or delayed …
autosomal dominant hypophosphatemic rickets (ADHR) disease onset at birth, or delayed …
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice
EG Farrow, X Yu, LJ Summers… - Proceedings of the …, 2011 - National Acad Sciences
Autosomal dominant hypophosphatemic rickets (ADHR) is unique among the disorders
involving Fibroblast growth factor 23 (FGF23) because individuals with R176Q/W and …
involving Fibroblast growth factor 23 (FGF23) because individuals with R176Q/W and …
Oral iron replacement normalizes fibroblast growth factor 23 in iron‐deficient patients with autosomal dominant hypophosphatemic rickets
Autosomal dominant hypophosphatemic rickets (ADHR) is caused by mutations impairing
cleavage of fibroblast growth factor 23 (FGF23). FGF23 gene expression increases during …
cleavage of fibroblast growth factor 23 (FGF23). FGF23 gene expression increases during …
Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans
EA Imel, M Peacock, AK Gray… - The Journal of …, 2011 - academic.oup.com
Context: In autosomal dominant hypophosphatemic rickets (ADHR), fibroblast growth factor
23 (FGF23) resists cleavage, causing increased plasma FGF23 levels. The clinical …
23 (FGF23) resists cleavage, causing increased plasma FGF23 levels. The clinical …
Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization
Y Ma, M Samaraweera, S Cooke-Hubley… - …, 2014 - academic.oup.com
Fibroblast growth factor-23 (FGF23) controls serum phosphorus largely through actions on
the kidneys to excrete phosphorus and reduce calcitriol. Although these actions are well …
the kidneys to excrete phosphorus and reduce calcitriol. Although these actions are well …
Regulation of fibroblast growth factor 23 by iron, EPO, and HIF
JA Wheeler, EL Clinkenbeard - Current molecular biology reports, 2019 - Springer
Abstract Purpose of Review Fibroblast growth factor-23 (FGF23) is the key hormone
produced in bone critical for phosphate homeostasis. Elevated serum phosphorus and 1, 25 …
produced in bone critical for phosphate homeostasis. Elevated serum phosphorus and 1, 25 …
Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women
M Wolf, TA Koch, DB Bregman - Journal of Bone and Mineral …, 2013 - academic.oup.com
ABSTRACT Fibroblast growth factor 23 (FGF23) is an osteocyte‐derived hormone that
regulates phosphate and vitamin D homeostasis. Through unknown mechanisms, certain …
regulates phosphate and vitamin D homeostasis. Through unknown mechanisms, certain …
FGF23 and disorders of phosphate homeostasis
X Yu, KE White - Cytokine & growth factor reviews, 2005 - Elsevier
It is well known that fibroblast growth factor (FGF) family members are associated with
embryonic development and are critical for basic metabolic functions. This review will focus …
embryonic development and are critical for basic metabolic functions. This review will focus …
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient …
D Sitara, MS Razzaque, M Hesse, S Yoganathan… - Matrix Biology, 2004 - Elsevier
Fibroblast growth factor-23 (FGF-23), a recently identified molecule that is mutated in
patients with autosomal dominant hypophosphatemic rickets (ADHR), appears to be …
patients with autosomal dominant hypophosphatemic rickets (ADHR), appears to be …
Transgenic mice expressing fibroblast growth factor 23 under the control of the α1 (I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed …
T Larsson, R Marsell, E Schipani, C Ohlsson… - …, 2004 - academic.oup.com
Mutations in the fibroblast growth factor 23 gene, FGF23, cause autosomal dominant
hypophosphatemic rickets (ADHR). The gene product, FGF-23, is produced by tumors from …
hypophosphatemic rickets (ADHR). The gene product, FGF-23, is produced by tumors from …