Characterization of the transcriptional regulatory network of the normal cell cycle is essential
for understanding the perturbations that lead to cancer. However, the complete set of cycling …

The genome-wide program of gene expression during the cell division cycle in a human
cancer cell line (HeLa) was characterized using cDNA microarrays. Transcripts of> 850 …

Background Cell division is central to the physiology and pathology of all eukaryotic
organisms. The molecular machinery underpinning the cell cycle has been studied …

We report here the transcriptional profiling of the cell cycle on a genome-wide scale in
human fibroblasts. We identified approximately 700 genes that display transcriptional …

With the completion of full genome sequences and advancement in high-throughput
technologies, in silico methods have been successfully used to integrate diverse data …

Human cells have evolved complex signaling networks to coordinate the cell cycle. A
detailed understanding of the global regulation of this fundamental process requires …

Progression through the cell cycle is largely dependent on waves of periodic gene
expression, and the regulatory networks for these transcriptome dynamics have emerged as …

Steady-state gene expression across the cell cycle has been studied extensively. However,
transcriptional gene regulation and the dynamics of histone modification at different cell …

The ordered expression of genes after growth factor stimulation in G1 supportsthe onset of
DNA replication. To characterize regulatory events during S-phase when cell cycle …

Patterns of gene expression in tumors can arise as a consequence of or result in genomic
instability, characterized by the accumulation of somatic copy number alterations (SCNAs) …