A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis
Nature communications, 2019 - nature.com
Genome-wide association studies (GWAS) have identified more than 50,000 unique
associations with common human traits. While this represents a substantial step forward …
associations with common human traits. While this represents a substantial step forward …
Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways
Background: Much effort has been expended on identifying the genetic determinants of
multiple sclerosis (MS). Existing large-scale genome-wide association study (GWAS) …
multiple sclerosis (MS). Existing large-scale genome-wide association study (GWAS) …
Genome-wide association studies in multiple sclerosis: lessons and future prospects
A Kemppinen, S Sawcer… - Briefings in functional …, 2011 - academic.oup.com
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with complex
aetiology. A haplotype within the major histocompatibility region is the major risk factor for …
aetiology. A haplotype within the major histocompatibility region is the major risk factor for …
Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls
SE Baranzini, P Khankhanian, NA Patsopoulos… - The American Journal of …, 2013 - cell.com
Multiple sclerosis (MS) is an inflammatory CNS disease with a substantial genetic
component, originally mapped to only the human leukocyte antigen (HLA) region. In the last …
component, originally mapped to only the human leukocyte antigen (HLA) region. In the last …
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis
SE Baranzini, NW Galwey, J Wang… - Human molecular …, 2009 - academic.oup.com
Genome-wide association studies (GWAS) testing several hundred thousand SNPs have
been performed in multiple sclerosis (MS) and other complex diseases. Typically, the …
been performed in multiple sclerosis (MS) and other complex diseases. Typically, the …
Genome‐wide association studies of multiple sclerosis
C Cotsapas, M Mitrovic - Clinical & translational immunology, 2018 - Wiley Online Library
Large‐scale genetic studies of multiple sclerosis have identified over 230 risk effects across
the human genome, making it a prototypical common disease with complex genetic …
the human genome, making it a prototypical common disease with complex genetic …
Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis
MD Ritchie - Genome Medicine, 2009 - Springer
The efforts of the Human Genome Project are beginning to provide important findings for
human health. Technological advances in the laboratory, particularly in characterizing …
human health. Technological advances in the laboratory, particularly in characterizing …
Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes
Genome-wide association studies (GWAS) successfully identified multiple sclerosis (MS)
susceptibility variants. Despite this notable progress, understanding the biological context of …
susceptibility variants. Despite this notable progress, understanding the biological context of …
Low-frequency and rare-coding variation contributes to multiple sclerosis risk
M Mitrovič, NA Patsopoulos, AH Beecham… - Cell, 2018 - cell.com
Multiple sclerosis is a complex neurological disease, with∼ 20% of risk heritability
attributable to common genetic variants, including> 230 identified by genome-wide …
attributable to common genetic variants, including> 230 identified by genome-wide …
A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches
VV Bashinskaya, OG Kulakova, AN Boyko, AV Favorov… - Human genetics, 2015 - Springer
Multiple sclerosis (MS) is a common complex neurodegenerative disease of the central
nervous system. It develops with autoimmune inflammation and demyelination. Genome …
nervous system. It develops with autoimmune inflammation and demyelination. Genome …