For more than three decades the National Heart, Lung, and Blood Institute (NHLBI) has
supported research and sponsored programs in basic cell biology and stem cell research …

A new window has just opened, illuminating a novel and unsuspected aspect of the
pathogenesis of heart failure. As we age, we accumulate somatic mutations in bone marrow …

Clonal hematopoiesis of indeterminate potential (CHIP) is defined as a clonal outgrowth of
hematopoietic cells with mutations in a restricted set of cancer driver genes in patients …

Importance Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal
expansion of hematopoietic stem cells with leukemogenic acquired genetic variants, is …

Clonal haematopoiesis and cardiovascular disease: how low can you go? Page 1 ...........................................................................................................
Clonal haematopoiesis and cardiovascular disease: how low can you go? Megan A. Evans …

Substantial advances in the past three decades, including risk-factor modification, use of
anticoagulants and antiplatelet agents, β blockers, angiotensin-convertingenzyme inhibitors …

Background Clonal hematopoiesis driven by somatic mutations in hematopoietic cells,
frequently called clonal hematopoiesis of indeterminate potential (CHIP), has been …

age-associated condition whereby a proportion of mature blood cells originate from a single
dominant hematopoietic stem cell (HSC) clone. This phenomenon can arise from a somatic …

Importance Somatic mutations causing clonal expansion of hematopoietic cells (clonal
hematopoiesis of indeterminate potential [CHIP]) are increased with age and associated …