Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction

TJ Bivalacqua, W Deng, M Kendirci… - American Journal …, 2007 - journals.physiology.org
Mesenchymal stem cells (MSCs) can be used in adult stem cell-based gene therapy for
vascular diseases. To test the hypothesis that MSCs alone or endothelial nitric oxide …

Effect of mesenchymal stem cell penile transplantation on erectile signaling of aged rats

MT Abdel Aziz, S El‐Haggar, T Mostafa, H Atta… - Andrologia, 2010 - Wiley Online Library
Stem cell‐based therapy targeted at the penile tissue has been lately considered in
preclinical studies. This work aimed to assess the effect of intracavernous administration of …

[HTML][HTML] Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury

Z Chen, X Han, X Ouyang, J Fang, X Huang, H Wei - Theranostics, 2019 - ncbi.nlm.nih.gov
Erectile dysfunction (ED) is an important kind of postoperative complication of pelvic surgery
that affects patients' quality of life. Transplantation of mesenchymal stem cells (MSC) has …

Intracavernous delivery of clonal mesenchymal stem cells restores erectile function in a mouse model of cavernous nerve injury

JK Ryu, DH Kim, KM Song, TG Yi… - The Journal of Sexual …, 2014 - academic.oup.com
Introduction Recently, much attention has focused on stem cell therapy; bone marrow‐
derived stem cells (BMSCs) are one of the most studied mesenchymal stem cells used in the …

Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells

YS Song, HJ Lee, IH Park, WK Kim, JH Ku… - International journal of …, 2007 - nature.com
One of the causes of erectile dysfunction (ED) is the damaged penile cavernous smooth
muscle cells (SMCs) and sinus endothelial cells (ECs). To investigate the feasibility of …

Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats

S Chen, J Zhu, M Wang, Y Huang… - International …, 2019 - spandidos-publications.com
The aim of the present study was to compare the effects of adipose‑derived mesenchymal
stem cell (ADSC) and bone marrow mesenchymal stem cell (BMSC) transplantation into the …

Adipose tissue–derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie's disease

A Gokce, ZY Abd Elmageed, GF Lasker… - …, 2014 - Wiley Online Library
Peyronie's disease (PD) is a localized connective tissue disorder that involves the tunica
albuginea (TA) of the penis. While surgical correction remains the gold standard, the search …

[HTML][HTML] Stem cells: novel players in the treatment of erectile dysfunction

H Zhang, M Albersen, X Jin, G Lin - Asian journal of andrology, 2012 - ncbi.nlm.nih.gov
Stem cells are defined by their capacity for both self-renewal and directed differentiation;
thus, they represent great promise for regenerative medicine. Historically, stem cells have …

Down-regulation of lncRNA MEG3 promotes endothelial differentiation of bone marrow derived mesenchymal stem cells in repairing erectile dysfunction

X Sun, L Luo, L Feng, D Li - Life sciences, 2018 - Elsevier
Aims In the treatment of diabetes mellitus associated erectile dysfunction (DMED), the
intracavernous and periprostatic implantations of bone marrow derived mesenchymal stem …

Extracellular vesicles from human urine-derived stem cells ameliorate erectile dysfunction in a diabetic rat model by delivering proangiogenic microRNA

B Ouyang, Y Xie, C Zhang, C Deng, L Lv, J Yao… - Sexual …, 2019 - academic.oup.com
Introduction Stem cell therapies represent a promising new frontier for the treatment of
refractory diabetic erectile dysfunction (DED). The use of stem cell-derived extracellular …