Replication timing is a crucial aspect of genome regulation that is strongly correlated with
chromatin structure, gene expression, DNA repair, and genome evolution. Replication timing …

Loading of the MCM replicative helicase at origins of replication is a highly regulated
process that precedes DNA replication in all eukaryotes. The stoichiometry of MCM loaded …

Recent work suggests that DNA replication origins are regulated by the number of multiple
mini‐chromosome maintenance (MCM) complexes loaded. Origins are defined by the …

The spatio-temporal program of genome replication across eukaryotes is thought to be
driven both by the uneven loading of pre-replication complexes (pre-RCs) across the …

In metazoan cells, only a limited number of mini chromosome maintenance (MCM)
complexes are fired during S phase, while the majority remain dormant. Several methods …

DNA replication must be tightly controlled during each cell cycle to prevent unscheduled
replication and ensure proper genome maintenance. The currently known controls that …

Background Early DNA replication occurs within actively transcribed chromatin
compartments in mammalian cells, raising the immediate question of how early DNA …

Eukaryotic chromosomes contain regions of varying accessibility, yet DNA replication factors
must access all regions. The first replication step is loading MCM complexes to license …

DNA replication is precisely regulated in time and space, thereby safeguarding genomic
integrity. In eukaryotes, replication initiates from multiple sites along the genome, termed …

Although the replication, expression, and maintenance of DNA are well-studied processes,
the way that they are coordinated is poorly understood. Here, we report an analysis of the …