Recent evidence suggests that alterations in insulin/insulin–like growth factor 1 (IGF1)
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …

We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1)
extends lifespan and increases resistance to several age-related pathologies in female …

Evidence is accumulating that aging is hormonally regulated by an evolutionarily conserved
insulin/IGF‐1 signalling (IIS) pathway. Mutations in IIS components affect lifespan in …

Growth hormone deficiency or resistance resulting from spontaneous or experimentally
produced mutations in laboratory mice delay aging and increase lifespan. Alterations in …

Although the underlying mechanisms of longevity are not fully understood, it is known that
mutation in genes that share similarities with those in humans involved in the insulin/insulin …

The causal relationships between insulin levels, insulin resistance, and longevity are not
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …

It has been demonstrated in invertebrate species that the evolutionarily conserved insulin
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …

Dampening of insulin/insulin‐like growth factor‐1 (IGF1) signaling results in the extension of
lifespan in invertebrate as well as murine models. The impact of this evolutionarily …

Recently, we have shown that compared to controls, long-lived familial nonagenarians
(mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate …

Rather than being a passive, haphazard process of wear and tear, lifespan can be
modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in …