Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion
T Fothergill, ALS Donahoo, A Douglass… - Cerebral …, 2014 - academic.oup.com
The left and right sides of the nervous system communicate via commissural axons that
cross the midline during development using evolutionarily conserved molecules. These …
cross the midline during development using evolutionarily conserved molecules. These …
[HTML][HTML] Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion
Background Longitudinal axons grow parallel to the embryonic midline to connect distant
regions of the central nervous system. Previous studies suggested that repulsive midline …
regions of the central nervous system. Previous studies suggested that repulsive midline …
Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin‐1
JF Bouchard, KE Horn, T Stroh… - Journal of …, 2008 - Wiley Online Library
The netrin‐1 receptor Deleted in Colorectal Cancer (DCC) is required for the formation of
major axonal projections by embryonic cortical neurons, including the corpus callosum …
major axonal projections by embryonic cortical neurons, including the corpus callosum …
[HTML][HTML] Netrin-1 derived from the ventricular zone, but not the floor plate, directs hindbrain commissural axons to the ventral midline
K Yamauchi, M Yamazaki, M Abe, K Sakimura… - Scientific reports, 2017 - nature.com
Abstract Netrin-1 (Ntn1) emanating from the ventral midline has been thought to act as a
long-range diffusible chemoattractant for commissural axons (CAs). However, CAs still grow …
long-range diffusible chemoattractant for commissural axons (CAs). However, CAs still grow …
[HTML][HTML] Revisiting netrin-1: one who guides (axons)
NP Boyer, SL Gupton - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …
postsynaptic partners; this entails microns to meters of extension through an extracellular …
[HTML][HTML] DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function
Coordinated limb rhythmic movements take place through organized signaling in local
spinal cord neuronal networks. The establishment of these circuitries during development is …
spinal cord neuronal networks. The establishment of these circuitries during development is …
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex …
M Shekarabi, SW Moore, NX Tritsch… - Journal of …, 2005 - Soc Neuroscience
Extracellular cues direct axon extension by regulating growth cone morphology. The netrin-1
receptor deleted in colorectal cancer (DCC) is required for commissural axon extension to …
receptor deleted in colorectal cancer (DCC) is required for commissural axon extension to …
[HTML][HTML] Developmental upregulation of Ephrin-B1 silences Sema3C/Neuropilin-1 signaling during post-crossing navigation of corpus callosum axons
The corpus callosum is the largest commissure in the brain, whose main function is to
ensure communication between homotopic regions of the cerebral cortex. During fetal …
ensure communication between homotopic regions of the cerebral cortex. During fetal …
Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system
The establishment of anatomically stereotyped axonal projections is fundamental to
neuronal function. While most neurons project their axons within the central nervous system …
neuronal function. While most neurons project their axons within the central nervous system …
Robo2–slit and Dcc–netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts
In the embryonic vertebrate brain, early born neurons establish highly stereotyped
embryonic axonal tracts along which the neuronal interconnections form. To understand the …
embryonic axonal tracts along which the neuronal interconnections form. To understand the …