Monogenic forms of childhood obesity due to mutations in the leptin gene | Molecular and
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Context: Congenital leptin deficiency is a very rare cause of severe early-onset obesity. We
recently characterized a mutation in the leptin gene (p. D100Y), which was associated with …

Congenital deficiency of the leptin receptor is a very rare cause of severe early-onset
obesity. To date, only 9 families have been reported in the literature to have mutations in the …

Congenital leptin deficiency is a rare, but treatable, cause of severe early-onset obesity. To
date, two United Kingdom families of Pakistani origin carrying a frameshift/premature stop …

Background Early childhood obesity is a public health problem worldwide. It affects different
aspects of physical and mental child's health. Identifying the etiologies, especially treatable …

Clément K. Leptin and the genetics of obesity. Acta Pædiatr 1999; Suppl 428: 51–7.
Stockholm. ISSN 0803–5326 The discovery of the Ob gene and its product, leptin, is a good …

Congenital leptin deficiency is a rare recessive genetic disorder resulting in severe
hyperphagia and early onset obesity. It is caused by mutations in the LEP gene encoding …

Background: Congenital leptin deficiency is a rare human genetic condition clinically
characterized by hyperphagia and acute weight gain usually during the first postnatal year …

Extremely unusual genetic conditions can reveal normal processes governing physiologic
regulation and metabolism. Children with rare homozygous mutations in the leptin gene and …

Leptin receptor gene mutations are a very rare cause of severe early-onset obesity. They are
also associated with lack of pubertal development and intense hyperphagia. Presented here …