[HTML][HTML] Exogenous overexpression of nerve growth factor in the urinary bladder produces bladder overactivity and altered micturition circuitry in the lumbosacral …

P Zvara, MA Vizzard - BMC physiology, 2007 - Springer
Background Exogenous NGF or saline was delivered to the detrusor smooth muscle of
female rats for a two-week period using osmotic mini-pumps. We then determined:(1) …

Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats

N Yoshimura, NE Bennett, Y Hayashi… - Journal of …, 2006 - Soc Neuroscience
Nerve growth factor (NGF) has been proposed as an important mediator inducing bladder
overactivity under pathological conditions such as spinal cord injury, bladder outlet …

Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats

S Seki, K Sasaki, Y Igawa, O Nishizawa… - The Journal of …, 2004 - auajournals.org
Purpose: We investigated the effects of intrathecal application of nerve growth factor (NGF)
antibodies (NGF-Abs) and desensitization of C-fiber afferent pathways by capsaicin …

The effect of neutralization of nerve growth factor (NGF) on bladder and urethral dysfunction in mice with spinal cord injury

N Wada, T Shimizu, N Shimizu… - Neurourology and …, 2018 - Wiley Online Library
Aims To investigate the role of nerve growth factor (NGF) in lower urinary tract dysfunction in
mice with spinal cord injury (SCI). Methods Using 4‐week SCI mice, single‐filling cystometry …

Immunoneutralization of nerve growth factor in lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats.

S Seki, K Sasaki, MO Fraser, Y Igawa… - The Journal of …, 2002 - auajournals.org
Purpose: We investigated the effects of intrathecal application of nerve growth factor (NGF)
antibodies (Ab) on bladder hyperreflexia in chronic spinalized rats. Materials and Methods …

Nerve growth factor in bladder dysfunction: contributing factor, biomarker, and therapeutic target

P Ochodnický, CD Cruz, N Yoshimura… - Neurourology and …, 2011 - Wiley Online Library
In the last two decades, nerve growth factor (NGF), initially described as a prototypical
trophic factor in the development of sensory and sympathetic innervation, has emerged as a …

Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction

MA Vizzard - Experimental neurology, 2000 - Elsevier
Spinal cord injury and cyclophosphamide-induced cystitis dramatically alter lower urinary
tract function and produce neurochemical, electrophysiological, and anatomical changes …

Immunity to nerve growth factor prevents afferent plasticity following urinary bladder hypertrophy

WD Steers, DJ Creedon, JB Tuttle - The Journal of urology, 1996 - auajournals.org
Purpose: The goal of this investigation was to examine the effect of immunity to nerve growth
factor (NGF) on alterations in sensory nerves from the urinary bladder in the dorsal root …

Neuromodulation reduces c-fos gene expression in spinalized rats: a double-blind randomized study

Y WANG, MM Hassouna - The Journal of urology, 2000 - Elsevier
PURPOSE: Neuromodulation of the sacral nerve roots is effective to treat various voiding
dysfunctions, but the underlying mechanism of neuromodulation is not known. The objective …

Therapeutic effects of inhibition of brain-derived neurotrophic factor on voiding dysfunction in mice with spinal cord injury

N Wada, T Shimizu, N Shimizu… - American Journal …, 2019 - journals.physiology.org
We investigated the involvement of brain-derived neurotrophic factor (BDNF) in bladder and
urethral dysfunction using spinal cord-injured mice. We evaluated bladder and urethral …