Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trials

BES Gibson, K Wheatley, IM Hann, RF Stevens… - Leukemia, 2005 - nature.com
Abstract Between 1988 and 2002, 758 children with acute myeloid leukaemia (AML) were
treated on Medical Research Council (MRC) AML 10 and AML 12. MRC AML 10 tested the …

Treatment‐related deaths during induction and first remission of acute myeloid leukaemia in children treated on the Tenth Medical Research Council Acute Myeloid …

LC Riley, IM Hann, K Wheatley… - British journal of …, 1999 - Wiley Online Library
Between 1988 and 1995, 341 children with acute myeloid leukaemia (AML) were treated on
the Medical Research Council Acute Myeloid Leukaemia Trial (MRC AML10). The 5‐year …

Outcome for children with relapsed acute myeloid leukaemia following initial therapy in the Medical Research Council (MRC) AML 10 trial

DKH Webb, K Wheatley, G Harrison, RF Stevens… - Leukemia, 1999 - nature.com
Abstract Between May 1988 and March 1995, 359 children with acute myeloid leukaemia
(AML) were treated in the MRC AML 10 trial. Three risk groups were identified based on …

Results of a randomized trial in children with Acute Myeloid Leukaemia: medical research council AML12 trial

BES Gibson, DKH Webb, AJ Howman… - British journal of …, 2011 - Wiley Online Library
Summary The Medical Research Council Acute Myeloid Leukaemia 12 (MRC AML12) trial
(children) addressed the optimal anthracenedione/anthracycline in induction and the …

Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukaemia: results of the United Kingdom Medical Research Council's 10th …

RF Stevens, IM Hann, K Wheatley… - British journal of …, 1998 - Wiley Online Library
359 eligible children with acute myeloid leukaemia (AML) entered the MRC AML 10 trial
between May 1988 and March 1995. Patients received four courses of intensive induction …

Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000

RC Ribeiro, BI Razzouk, S Pounds, N Hijiya, CH Pui… - Leukemia, 2005 - nature.com
Despite substantial progress in the management of childhood acute myeloid leukemia
(AML), only about 50% of patients are cured by intensive chemotherapy. The long-term …

Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000

Y Ravindranath, M Chang, CP Steuber, D Becton… - Leukemia, 2005 - nature.com
From 1981 to 2000, a total of 1823 children with acute myeloid leukemia (AML) enrolled on
four consecutive Pediatric Oncology Group (POG) clinical trials. POG 8101 demonstrated …

Improved outcome after relapse in children with acute myeloid leukaemia

J Abrahamsson, N Clausen… - British journal of …, 2007 - Wiley Online Library
Summary In the Nordic Society for Paediatric Haematology and Oncology paediatric study
acute myeloid leukaemia (AML) 93, event‐free survival was 50% and overall survival was …

A comparison of allogeneic bone marrow transplantation, autologous bone marrow transplantation, and aggressive chemotherapy in children with acute myeloid …

WG Woods, S Neudorf, S Gold… - Blood, The Journal …, 2001 - ashpublications.org
Intensive, myelosuppressive therapy is necessary to maximize outcomes for patients with
acute myeloid leukemia (AML). A comparison was made of 3 aggressive postremission …

Comparison of bone marrow transplant and chemotherapy for relapsed childhood acute lymphoblastic leukaemia: the MRC UKALL X experience

K Wheeler, S Richards, C Bailey… - British journal of …, 1998 - Wiley Online Library
We examined the outcome of the 489 children with acute lymphoblastic leukaemia (ALL)
who relapsed in the UKALL X trial, and produced graphical displays of adjusted …