We have used the aberrant crypt focus (ACF) assay to test and develop hypotheses linking
diet and colon cancer. The hypotheses were suggested by epidemiological studies that …

Comparative international epidemiological data indicate that the difference between the
highest and lowest colon cancer incidence is approximately 10-fold. This suggests that the …

Progress in the field of diet and colon cancer would be greatly enhanced by the
development of a methodology which allowed for the identification and quantification of the …

The effects of different dietary compounds on the formation of aberrant crypt foci (ACF) and
colorectal tumours and on the expression of a selection of genes were studied in rats …

High intake of red meat or processed meat is associated with increased risk of colon cancer.
In contrast, consumption of white meat (chicken) is not associated with risk and might even …

Two recent developments in cancer epidemiology and experimental carcinogenesis provide
the basis for two possible mechanisms relating diet and colon cancer risk. The first …

Recent investigations have established that caloric restriction (CR) reduces end tumor
incidence in the rat colon. The present study was conducted to determine whether CR at the …

Aberrant crypt foci can be identified in the colons of rodents treated 3 wk earlier with
azoxymethane, a known colon carcinogen. These crypts can easily be visualized in the …

We assessed the effects of 41 potential chemopreventive agents in the F344 rat using the
inhibition of carcinogen-induced aberrant crypt foci (ACF) in the colon as the measure of …

Animal models provide a unique opportunity to study the biology of the disease process, and
to test hypotheses linking environmental factors in the etiology and prevention of colon …