Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-β: prodromal Alzheimer's disease?

YY Lim, KA Ellis, K Harrington… - Journal of …, 2013 - content.iospress.com
We aimed to characterize the nature and magnitude of cognitive decline in a group of adults
with amnestic mild cognitive impairment (aMCI) with high and low levels of amyloid-(A) in …

Cognitive consequences of high Aβ amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of Alzheimer's disease.

YY Lim, KA Ellis, K Harrington, A Kamer… - …, 2013 - psycnet.apa.org
Background: It has been proposed that only mild cognitive impairment (MCI) with high Aβ
amyloid is indicative of incipient Alzheimer's disease (AD), yet MCI with low Aβ amyloid may …

Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease

YY Lim, P Maruff, RH Pietrzak, D Ames, KA Ellis… - Brain, 2014 - academic.oup.com
High amyloid has been associated with substantial episodic memory decline over 18 and 36
months in healthy older adults and individuals with mild cognitive impairment. However, the …

Decline in cognitive function over 18 months in healthy older adults with high amyloid-β

KA Ellis, YY Lim, K Harrington, D Ames… - Journal of …, 2013 - content.iospress.com
We aimed to characterize the nature and magnitude of cognitive decline in a group of
healthy older adults with high and low levels of amyloid-(A) and who were APOE 4 carriers …

Amyloid-β related memory decline is not associated with subjective or informant rated cognitive impairment in healthy adults

S Hollands, YY Lim, R Buckley… - Journal of …, 2015 - content.iospress.com
Background: The detection of early Alzheimer's disease (AD) can rely on subjective and
informant reports of cognitive impairment. However, relationships between subjective …

Mild cognitive impairment due to Alzheimer disease is less likely under the age of 65

S Shin, JH Kim, JH Cho, GS Kim, SA Choi… - Alzheimer Disease & …, 2015 - journals.lww.com
Patients with amnestic mild cognitive impairment (aMCI) are considered to have a high risk
for Alzheimer dementia (AD). Even high positive predictive values, however, cannot be …

[HTML][HTML] Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloid-negative amnestic mild cognitive impairment patients

C Tomadesso, V de La Sayette, R de Flores… - Alzheimer's & Dementia …, 2018 - Elsevier
Introduction Patients with amnestic mild cognitive impairment (aMCI) are heterogeneous as
regard to their amyloid status. The present study aimed at highlighting the …

The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI

KD Harrington, YY Lim, KA Ellis, C Copolov… - International …, 2013 - cambridge.org
Background: To date evidence of the relationship between cognition and Aβ amyloid during
the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to …

A biomarker study in long-lasting amnestic mild cognitive impairment

C Cerami, A Dodich, S Iannaccone, G Magnani… - Alzheimer's research & …, 2018 - Springer
Background Mild cognitive impairment (MCI) is a heterogeneous syndrome resulting from
Alzheimer's disease (AD) as well as to non-AD and non-neurodegenerative conditions. A …

Amyloid pathology in the progression to mild cognitive impairment

PS Insel, O Hansson, RS Mackin, M Weiner… - Neurobiology of …, 2018 - Elsevier
The objective of this study was to determine the cognitive and functional decline and
development of brain injury in individuals progressing from preclinical (β-amyloid positive …