Mechanistic links between oxidative/nitrosative stress and tumor necrosis factor alpha in letrozole-induced murine polycystic ovary: biochemical and pathological …

MA Rezvanfar, MA Rezvanfar… - Human & …, 2012 - journals.sagepub.com
This study aimed to investigate the possible relationship between ovarian functionality and
the oxidative response during cystogenesis induced by hyperandrogenization with letrozole …

Role of oxidative stress and low-grade inflammation in letrozole-induced polycystic ovary syndrome in the rat

V Pandey, A Singh, A Singh, A Krishna, U Pandey… - Reproductive …, 2016 - Elsevier
The aims of the current study were to examine the effects of temporal changes in oxidative
stress (OS) and low-grade inflammation in letrozole-treated rats and to correlate these …

Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary

MA Rezvanfar, S Saadat, HAS Saadi, P Mansoori… - Theriogenology, 2015 - Elsevier
Chronic low-grade inflammation and oxidative stress (OS) appear to be two main pathways
involved in the pathogenesis of polycystic ovary (PCO) syndrome. Therefore, targeting these …

[HTML][HTML] An experimental study on the oxidative status and inflammatory levels of a rat model of polycystic ovary syndrome induced by letrozole and a new high-fat diet

SF Mirseyyed, S Zavareh, M Nasiri… - … Journal of Fertility & …, 2024 - ncbi.nlm.nih.gov
Background: Although there are numerous animal models of polycystic ovary syndrome
(PCOS), they often fail to accurately replicate the reproductive and metabolic phenotypes …

Dual targeting of TNF-α and free radical toxic stress as a promising strategy to manage experimental polycystic ovary

MA Rezvanfar, S Saeedi, P Mansoori… - Pharmaceutical …, 2016 - Taylor & Francis
Context: It is now clear that oxidative stress (OS) and chronic low-grade inflammation are
two main pathways involved in polycystic ovary syndrome (PCOS) pathogenesis. Therefore …

Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats

A Ullah, S Jahan, S Razak, M Pirzada, H Ullah… - Journal of Ovarian …, 2017 - Springer
Background PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually
taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne …

[PDF][PDF] Letrozole vs estradiol valerate induced PCOS in rats: glycemic, oxidative and inflammatory status assessment

A Daneasa, C Cucolas, LM Lenghel, D Olteanu… - …, 2016 - scholar.archive.org
The objective of our study was to investigate glycemic, oxidative/antioxidative and
inflammatory status in letrozole and estradiol valerate induced polycystic ovarian syndrome …

Dysregulation of intraovarian redox status and steroidogenesis pathway in letrozole-induced PCOS rat model: a possible modulatory role of l-Carnitine

SH Elmosalamy, EMM Elleithy, ZSO Ahmed… - Beni-Suef University …, 2022 - Springer
Background Polycystic ovarian syndrome (PCOS) is a reproductive disorder associated with
several endocrine and metabolic alterations. The mechanism underlying this syndrome is …

Pathophysiological changes in experimental polycystic ovary syndrome in female albino rats: Using either hemin or L‐arginine

MM Ragy, HA Abdel‐Hamid… - Journal of cellular …, 2019 - Wiley Online Library
Polycystic ovary syndrome (PCOS), one of the important endocrine disorders affecting
females in the reproductive age, is caused mainly by an abnormal oxidation status that …

Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS

KS Olaniyi, AA Oniyide, OA Adeyanju, LS Ojulari… - Toxicology and Applied …, 2021 - Elsevier
Polycystic ovarian syndrome (PCOS), is a multifactorial endocrine disorder in women of
reproductive age. It usually associates with metabolic disorders (MDs), which aggravates the …