The nucleoprotein filament (NPF) is the fundamental element of homologous recombination
(HR), a major mechanism for the repair of double-strand DNA breaks in the cell. The NPF is …

Figure 6 RAD51 filament formation at the single-molecule level using DNA manipulation. 23
Figure 7 RAD51 filament formation at the single-molecule level using fluorescence …

I am a biophysicist who is passionate about understanding how different kind of stresses can
alter molecular organization and dynamics and the resulting consequences on cell …

XPC protein recognizes diverse DNA lesions including ultraviolet-photolesions and
carcinogen-DNA adducts, initiating nucleotide excision repair. Structural studies showed …

In selecting ss DNA over ds DNA, the RAD 51 DNA strand exchange protein has to
overcome the entropy associated with straightening of single‐strand DNA upon …

Nucleoprotein filament formation by recombinases is central to homologous recombination.
To follow this process, we used fluorescent human Rad51 recombinase to visualize the …

Preserving the genomic integrity stands a fundamental necessity, primarily achieved by the
DNA repair proteins through their continuous patrolling on the DNA in search of lesions …

The timely activation of homologous recombination is essential for the maintenance of
genome stability, in which the RAD 51 recombinase plays a central role. Biochemically …

XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-
destabilizing/distorting DNA lesions by selectively 'opening'these sites while rapidly diffusing …

Homologous recombination (HR) is a high-fidelity repair mechanism for double-strand
breaks. Rad51 is the key enzyme that forms filaments on single-stranded DNA (ssDNA) to …