PURPOSE: Cardiopulmonary bypass (CPB) procedures are thought to activate systemic
inflammatory reaction syndrome (SIRS). Strategies to curb systemic inflammation have been …

Fig. 1-Latest impact factors of BJCVS. is driven by ischemia-reperfusion injury (I/R injury),
endotoxemia, coagulation disorders, and reactions to heparin/protamine. The contact of …

Background Recent study of the inflammatory reactions occurring during and after
cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the …

Cardiopulmonary bypass (CPB) is known to cause a systemic inflammatory response.
Inflammation includes several cascade activations: complement, cytokine, and coagulation …

Introduction: Cardiopulmonary bypass (CPB) induces an inflammatory response believed to
contribute to postoperative morbidity. We hypothesized that the magnitude of the …

Previous studies showed that cardiopulmonary bypass (CPB) was directly associated with a
global activation of the inflammatory response, production of oxygen free radicals, and signs …

The lack of established cause and effect between putative mediators of inflammation and
adverse clinical outcomes has been responsible for many failed anti-inflammatory …

Cardiac surgery using cardiopulmonary bypass (CPB) provokes a systemic inflammatory
response. This is mainly triggered by contact activation of blood by artificial surfaces of the …

Cardiac surgery has been routinely performed using cardiopulmonary bypass (CPB) ever
since its clinical introduction during the 1950s. CPB is, however, associated with an intense …

The causal factors of the systemic inflammatory response to cardiopulmonary bypass (CPB)
were correctly identified in the early 1990s:"… activation of complement, coagulation …